Vision related quality of life in spinocerebellar ataxia

Abstract Objective Spinocerebellar ataxia (SCA) leads to abnormal ocular motility and alignment. The objective of this study was to quantitatively assess vision, ocular motility and alignment and its impact on vision related quality of life (VRQOL) in SCA. Methods Nineteen genetically diagnosed SCA...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the neurological sciences 2015-11, Vol.358 (1), p.404-408
Main Authors: Kedar, Sachin, Ghate, Deepta, Murray, Earnest L, Corbett, James J, Subramony, S.H
Format: Article
Language:English
Subjects:
Adult
Aged
Contrast Sensitivity - physiology
Diplopia
Female
Humans
Male
Middle Aged
Neurology
Nystagmus
Ocular motility
Ocular Motility Disorders - etiology
Ocular Motility Disorders - physiopathology
Quality of Life
Spinocerebellar ataxia
Spinocerebellar Ataxias - complications
Spinocerebellar Ataxias - physiopathology
Vision
Vision Disorders - etiology
Vision Disorders - physiopathology
Visual Acuity - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Objective Spinocerebellar ataxia (SCA) leads to abnormal ocular motility and alignment. The objective of this study was to quantitatively assess vision, ocular motility and alignment and its impact on vision related quality of life (VRQOL) in SCA. Methods Nineteen genetically diagnosed SCA subjects (11 SCA type 3, 3 SCA type 1 and 5 SCA type 6) participated at two university centers. All subjects completed the National Eye Institute Visual Function Questionnaire (NEI-VFQ), 10-Item Neuro-Ophthalmic Supplement (NOS), scale for assessment and rating of ataxia (SARA) and ophthalmic examination. Twelve subjects seen at one of the 2 sites underwent quantitative ocular motility and alignment assessment. Results Composite scores for NEI-VFQ (mean 76.3 ± 13) and NOS (mean 65.2 ± 16.8) were significantly decreased in SCA subjects. NEI-VFQ subscale scores were decreased for general, near, distance and peripheral vision and driving. SCA patients had decreased low contrast sensitivity, stereoacuity and multiple ocular motility defects which included gaze limitation (9/12), nystagmus (5/12), distance esophoria (11/12), near exophoria (12/12) and receded near point of convergence. A significant negative correlation was noted between composite scores and distance convergence fusional amplitude. Conclusion VRQOL is significantly decreased in SCA compared to normal population. All SCA patients should be screened for visual disability and referred for neuro-ophthalmic assessment promptly.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2015.10.013