Effective targeting of primitive AML CD34+ cells by the second‐generation proteasome inhibitor carfilzomib

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Bibliographic Details
Published in:British journal of haematology 2015-11, Vol.171 (4), p.652-655
Main Authors: Helm, Lieke H., Bosman, Matthieu C.J., Schuringa, Jan J., Vellenga, Edo
Format: Article
Language:English
Subjects:
acute leukaemia
bortezomib
Bortezomib - pharmacology
carfilzomib
Drug Screening Assays, Antitumor
Genes, Reporter
Green Fluorescent Proteins - genetics
Green Fluorescent Proteins - metabolism
HL-60 Cells
Humans
Leukemia, Myeloid, Acute - pathology
Neoplasm Proteins - metabolism
Oligopeptides - pharmacology
oprozomib
Proteasome Endopeptidase Complex - metabolism
Proteasome Inhibitors - pharmacology
Proteolysis
stem cells
Tumor Cells, Cultured
Tumor Stem Cell Assay
Online Access:Get full text
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ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.13418