Quantifying transient interactions between amide groups and the guanidinium cation

We study the interaction of the guanidinium cation, a widely used protein denaturant, with amide groups, the common structural motif of proteins. Our results provide evidence for direct contact between guanidinium and ∼2 amide groups, but the interaction is transient and weaker than for other cation...

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Bibliographic Details
Published in:Physical chemistry chemical physics : PCCP 2015-01, Vol.17 (43), p.28539-28543
Main Authors: Balos, V, Bonn, M, Hunger, J
Format: Article
Language:English
Subjects:
Acetamides - chemistry
Amides
Amides - chemistry
Cations
Contact
Entropy
Guanidine - chemistry
Physical chemistry
Protein Denaturation
Proteins
Proteins - chemistry
Proteins - metabolism
Water - chemistry
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Summary:We study the interaction of the guanidinium cation, a widely used protein denaturant, with amide groups, the common structural motif of proteins. Our results provide evidence for direct contact between guanidinium and ∼2 amide groups, but the interaction is transient and weaker than for other cations with high charge-density. The guanidinium cation interacts with amide groups, the interaction strength is - compared to other cations - only intermediate.
ISSN:1463-9076
1463-9084
DOI:10.1039/c5cp04619j