Serum fetuin-A concentrations are positively associated with serum VEGF levels in patients with newly diagnosed type 2 diabetes

Fetuin-A was considered to be involved in pathogenesis of type 2 diabetes. On the other hand, higher vascular endothelial growth factor (VEGF) expression is associated with diabetes and its vascular complications, but the mechanisms leading to higher VEGF levels are still not clear. To the best of o...

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Bibliographic Details
Published in:Endocrine Journal 2015, Vol.62(10), pp.879-885
Main Authors: Zhou, Zhongwei, Ju, Huixiang, Sun, Mingzhong, Chen, Hongmei, Ji, Hongbin, Jiang, Dongmei, Ji, Yuqiao, Ji, Jianwei
Format: Article
Language:English
Subjects:
Adult
alpha-2-HS-Glycoprotein - analysis
Blood Glucose - analysis
C-Reactive Protein - analysis
China
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - blood
Enzyme-Linked Immunosorbent Assay
Female
Fetuin-A
Glycated Hemoglobin A - analysis
Hospitals, University
Humans
Linear Models
Male
Middle Aged
Multivariate Analysis
Outpatient Clinics, Hospital
Reproducibility of Results
Type 2 diabetes
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - blood
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Summary:Fetuin-A was considered to be involved in pathogenesis of type 2 diabetes. On the other hand, higher vascular endothelial growth factor (VEGF) expression is associated with diabetes and its vascular complications, but the mechanisms leading to higher VEGF levels are still not clear. To the best of our knowledge, there are no data to show the associations between fetuin-A and VEGF in patients with type 2 diabetes. Therefore, the aim of this study is to investigate the relationship between serum fetuin-A concentrations and serum VEGF levels in patients with type 2 diabetes. We recruited 345 patients with newly diagnosed type 2 diabetes. Serum fetuin-A concentrations and serum VEGF levels were measured using enzyme-linked immunosorbent assay (ELISA) method. In this study, there was a significant positive correlation between serum fetuin-A concentrations and serum VEGF levels (r=0.223, P
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.EJ15-0152