Damped oscillations in a multiple delayed feedback NF-κB signaling module

The NF- κ B signaling system regulates a number of cellular processes. Recent studies with simplified models found a damped function of the dual delayed feedback NF- κ B signaling module. We use a computational model to investigate how multiple delayed feedback aids achieving damping oscillation in...

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Bibliographic Details
Published in:European biophysics journal 2015-12, Vol.44 (8), p.677-684
Main Authors: Yu, Wen-Ting, Tang, Jun, Ma, Jun, Luo, Jin-Ming, Yang, Xian-Qing
Format: Article
Language:English
Subjects:
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Cell Biology
Feedback, Physiological
Life Sciences
Membrane Biology
Models, Theoretical
Nanotechnology
Neurobiology
NF-kappa B - metabolism
Original Paper
Periodicity
Reaction Time
Signal Transduction
Citations: Items that this one cites
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Description
Summary:The NF- κ B signaling system regulates a number of cellular processes. Recent studies with simplified models found a damped function of the dual delayed feedback NF- κ B signaling module. We use a computational model to investigate how multiple delayed feedback aids achieving damping oscillation in the system and how internal noise can influence the damping function. A curve-fitting method (CFM) is introduced to quantify the damped oscillation. Our results show that (1) the structure of multiple delayed feedback, containing double or triple significantly delayed feedback, determines achieving damped oscillation. (2) Internal noise could aid the system to achieve damped oscillation under almost all circumstances.
ISSN:0175-7571
1432-1017
DOI:10.1007/s00249-015-1066-1