Gene Polymorphisms of the Mu Opioid Receptor in Methamphetamine Abusers

: In drug addiction, the opioid system is thought to mediate motivational effects through dopamine‐independent mechanisms. We have investigated associations of the μ‐opioid receptor gene (OPRM) variations with methamphetamine (MAP) dependence/psychosis. The allelic frequency of A118G (Asn40Asp) in e...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2004-10, Vol.1025 (1), p.316-324
Main Authors: IDE, SOICHIRO, KOBAYASHI, HIDEAKI, TANAKA, KEIKO, UJIKE, HIROSHI, SEKINE, YOSHIMOTO, OZAKI, NORIO, INADA, TOSHIYA, HARANO, MUTSUO, KOMIYAMA, TOKUTARO, YAMADA, MITSUHIKO, IYO, MASAOMI, IKEDA, KAZUTAKA, SORA, ICHIRO
Format: Article
Language:English
Subjects:
Adult
Amphetamine-Related Disorders - genetics
Amphetamine-Related Disorders - metabolism
Chi-Square Distribution
dependence
Female
Gene Frequency - genetics
human μ-opioid receptor gene
Humans
Male
Methamphetamine
Monte Carlo Method
nucleotide repeats
Polymorphism, Genetic - genetics
psychosis
Receptors, Opioid, mu - genetics
single nucleotide polymorphism
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Summary:: In drug addiction, the opioid system is thought to mediate motivational effects through dopamine‐independent mechanisms. We have investigated associations of the μ‐opioid receptor gene (OPRM) variations with methamphetamine (MAP) dependence/psychosis. The allelic frequency of A118G (Asn40Asp) in exon 1 of ORPM was 45.3% in our control subjects, but only 7.5‐25.8% in the Caucasian or African‐American population of previous studies. We have identified several novel polymorphisms in intron 1 and the 5′ untranslated region (5′UTR) of OPRM. Polymorphisms in the functionally relevant 5′ regulatory region of OPRM were different in our Japanese population from Caucasian or African‐American populations. No significant differences between controls and MAP abusers were found in either genotype or allele frequency at any single nucleotide polymorphism (SNP) or (AC)n dinucleotide repeat in intron 1. A subdivision of our MAP group revealed that A118G of OPRM shows a significant association with MAP psychosis having latency less than three years. Further analysis should be capable of identifying associations between the OPRM variations and MAP dependence/psychosis.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1316.039