Metabolism of GABA in retina of diabetic rat

The effect of hyperglycemia on the localization and metabolism of gamma-aminobutyric acid (GABA) was examined to elucidate the pathogenesis of deteriorations of electroretinogram oscillatory potentials in streptozotocin-induced diabetic rats. GABA is localized primarily in amacrine cells in the diab...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience research communications 1999-02, Vol.24 (1), p.27-32
Main Authors: Honda, Misao, Ino-ue, Masanori, Okada, Yasuhiro, Yamamoto, Misao
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of hyperglycemia on the localization and metabolism of gamma-aminobutyric acid (GABA) was examined to elucidate the pathogenesis of deteriorations of electroretinogram oscillatory potentials in streptozotocin-induced diabetic rats. GABA is localized primarily in amacrine cells in the diabetic retina. GABA content and activities of glutamate decarboxylase (GAD) and GABA transaminase (GABA-T) in the retina and superior colliculus (SC) were determined. GABA content and activities of GAD and GABA-T remained unchanged in retinas and SCs of diabetic rats. Alterations in the GABAnergic system of the retina could not be observed. GABA metabolism may have no relation with visual dysfunction in diabetes mellitus.
ISSN:0893-6609
DOI:10.1002/(SICI)1520-6769(199901/02)24:1<27::AID-NRC4>3.3.CO;2-Q