Neuronal outgrowth of PC-12 cells after combined treatment with nerve growth factor and a magnetic field: Influence of the induced electric field strength

In view of possible therapeutic applications of magnetic fields, the effect of an enhancement of neuronal outgrowth at higher figures of flux density and induced field strength was investigated. On the average sinusoidal magnetic field treatment at 100 μTrms/50 Hz did not change nerve growth factor...

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Bibliographic Details
Published in:Bioelectromagnetics 2005-01, Vol.26 (1), p.74-77
Main Authors: Schimmelpfeng, J., Weibezahn, K.-F., Dertinger, H.
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation - drug effects
Cell Differentiation - radiation effects
Cell Enlargement - drug effects
Cell Enlargement - radiation effects
Cell Line
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Drug Tolerance - radiation effects
electric field strength
Electromagnetic Fields
ELF fields
Nerve Growth Factor - pharmacology
neurite outgrowth
Neurites - drug effects
Neurites - physiology
Neurites - radiation effects
Neurites - ultrastructure
neuronal differentiation
Neurons - cytology
Neurons - drug effects
Neurons - physiology
Neurons - radiation effects
NGF
Radiation Dosage
Rats
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Summary:In view of possible therapeutic applications of magnetic fields, the effect of an enhancement of neuronal outgrowth at higher figures of flux density and induced field strength was investigated. On the average sinusoidal magnetic field treatment at 100 μTrms/50 Hz did not change nerve growth factor (NGF) induced neurite outgrowth to a statistically significant extent. These results suggest that further increasing the induced field strength by using either higher flux densities and/or more sophisticated wave forms might be necessary to cause the neuronal response of PC‐12 cells, as seen in other experiments. Bioelectromagnetics 26:74–77, 2005. © 2004 Wiley‐Liss, Inc.
ISSN:0197-8462
1521-186X
DOI:10.1002/bem.20073