Collision-Induced Dissociation Mass Spectrometry: A Powerful Tool for Natural Product Structure Elucidation

Mass spectrometry is a powerful tool in natural product structure elucidation, but our ability to directly correlate fragmentation spectra to these structures lags far behind similar efforts in peptide sequencing and proteomics. Often, manual data interpretation is required and our knowledge of the...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2015-11, Vol.87 (21), p.10668-10678
Main Authors: Johnson, Andrew R, Carlson, Erin E
Format: Article
Language:English
Subjects:
Aminoglycosides - chemistry
Biological Products - chemistry
Chemistry Techniques, Analytical - instrumentation
Mass Spectrometry
Molecular Structure
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Summary:Mass spectrometry is a powerful tool in natural product structure elucidation, but our ability to directly correlate fragmentation spectra to these structures lags far behind similar efforts in peptide sequencing and proteomics. Often, manual data interpretation is required and our knowledge of the expected fragmentation patterns for many scaffolds is limited, further complicating analysis. Here, we summarize advances in natural product structure elucidation based upon the application of collision induced dissociation fragmentation mechanisms.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.5b01543