Predictive value of biomarkers for the prognosis of acute pulmonary embolism in Japanese patients: Results of the Tokyo CCU Network registry

Abstract Background Several studies from Western countries have reported associations between cardiac troponin and B-type natriuretic peptide (BNP) levels and acute pulmonary embolism prognosis; however, the number of such reports from Asian countries, including Japan, is limited. Thus, we evaluated...

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Bibliographic Details
Published in:Journal of cardiology 2015-12, Vol.66 (6), p.460-465
Main Authors: Tanabe, Yasuhiro, MD, Obayashi, Toru, MD, PhD, Yamamoto, Takeshi, MD, PhD, Takayama, Morimasa, MD, PhD, Nagao, Ken, MD, PhD
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Aged
Aged, 80 and over
B-type natriuretic peptide
Biomarkers - blood
Blood biomarkers
Blood Glucose - analysis
Cardiovascular
Female
Humans
Hyperglycemia
Japan
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Prognosis
Pulmonary embolism
Pulmonary Embolism - blood
Pulmonary Embolism - mortality
Registries
Tokyo
Troponin
Troponin - blood
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Summary:Abstract Background Several studies from Western countries have reported associations between cardiac troponin and B-type natriuretic peptide (BNP) levels and acute pulmonary embolism prognosis; however, the number of such reports from Asian countries, including Japan, is limited. Thus, we evaluated the relationship between blood biochemical findings and acute-phase pulmonary embolism prognosis in Japanese patients. Methods The subjects included 441 patients with acute pulmonary embolism (191 men, 250 women; average age, 65.8 ± 16.0 years) treated at Tokyo CCU Network Institutions from 2009 to 2011 and registered via survey forms. The association between blood biochemical findings at admission and 30-day mortality was investigated. Results The median BNP value was 186.5 pg/mL (25th to 75th interquartile range: 49.8–500 pg/mL) of 210 cases. No deaths were recorded among those with BNP levels
ISSN:0914-5087
1876-4738
DOI:10.1016/j.jjcc.2015.03.002