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MRI-based relationships between spine pathology, intervertebral disc degeneration, and muscle fatty infiltration in chondrodystrophic and non-chondrodystrophic dogs

Abstract Background Context Human studies have revealed a link between muscle degeneration and low back pain, although the cause and effect of this relationship is not clear. Dogs provide a naturally developing model of intervertebral disc (IVD)-related low back pain that may provide insight into re...

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Bibliographic Details
Published in:The spine journal 2015-11, Vol.15 (11), p.2433-2439
Main Authors: Lerer, Assaf, DVM, Nykamp, Stephanie G., DVM, Harriss, Alexandra B., MSc, Gibson, Thomas W.G., DVM, Koch, Thomas G., DVM, PhD, Brown, Stephen H.M., PhD
Format: Article
Language:English
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Summary:Abstract Background Context Human studies have revealed a link between muscle degeneration and low back pain, although the cause and effect of this relationship is not clear. Dogs provide a naturally developing model of intervertebral disc (IVD)-related low back pain that may provide insight into relationships between IVD and muscle degeneration. Purpose This study aimed to quantify, via magnetic resonance imaging (MRI), the magnitude and location of fatty infiltration in spine muscles of chondrodystrophic (CD) and non-chondrodystrophic (NCD) dogs suffering from both intervertebral disc herniation (IVDH) and non-disc-related spinal disorders, and relate this to intervertebral disc degeneration (IVDD). Study Design This study used retrospective MRI-based analysis of IVDD and muscle fatty infiltration in CD and NCD dogs. Methods A portion of this study was funded ($1,000) by the Pet Trust Fund, Ontario Veterinary College. Magnetic resonance imaging from 180 dogs were separated into four groups: (1) CD with IVDH; (2) CD with non-IVDH spinal pathology; (3) NCD with IVDH; (4) NCD with non-IVDH spinal pathology. For each dog at intervertebral levels T12–T13 to L6–L7, IVDD was subjectively graded and muscle-fat indices (MFIndices) were quantified for multifidus, erector spinae, and psoas muscle groups. Results Intervertebral disc degeneration grade was higher (p
ISSN:1529-9430
1878-1632
DOI:10.1016/j.spinee.2015.08.014