A novel curcumin–artemisinin coamorphous solid: physical properties and pharmacokinetic profile

Here we report a curcumin–artemisinin coamorphous solid (1 : 1) prepared by rotavaporization and a dramatic increase in the pharmacokinetic profile of curcumin (AUC 0–12 2.6 μg h mL −1 , C max 1 μg mL −1 ) administered as CUR–ART to SD rats. PXRD and FESEM analysis explains the molecular basis for t...

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Bibliographic Details
Published in:RSC advances 2014-01, Vol.4 (102), p.58357-58361
Main Authors: Suresh, Kuthuru, Mannava, M. K. Chaitanya, Nangia, Ashwini
Format: Article
Language:English
Subjects:
Physical properties
Rats
Solubility
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Summary:Here we report a curcumin–artemisinin coamorphous solid (1 : 1) prepared by rotavaporization and a dramatic increase in the pharmacokinetic profile of curcumin (AUC 0–12 2.6 μg h mL −1 , C max 1 μg mL −1 ) administered as CUR–ART to SD rats. PXRD and FESEM analysis explains the molecular basis for the solubility enhancement of coamorphous CUR–ART .
ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA11935E