An eco-friendly synthesis of novel 3,5-disubstituted-1,2-isoxazoles in PEG-400, employing the Et sub(3)N-promoted hydroamination of symmetric and unsymmetric 1,3-diyne-indole derivatives

A facile, efficient and atom-economic synthesis of 3,5-disubstituted 1,2-isoxazoles bearing indole moieties, is reported. The synthesis of these isoxazoles was carried out by the triethylamine-promoted reaction of symmetric and unsymmetric 1,3-diyne indole derivatives with hydroxylamine in PEG-400,...

Full description

Saved in:
Bibliographic Details
Published in:RSC advances 2014-11, Vol.4 (105), p.60785-60797
Main Authors: Bassaco, Mariana M, tes, Margiani P, Back, Davi F, Kaufman, Teodoro S, Silveira, Claudio C
Format: Article
Language:English
Subjects:
Catalysis
Copper
Derivatives
Indoles
Nickel
Solvents
Symmetry
Synthesis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A facile, efficient and atom-economic synthesis of 3,5-disubstituted 1,2-isoxazoles bearing indole moieties, is reported. The synthesis of these isoxazoles was carried out by the triethylamine-promoted reaction of symmetric and unsymmetric 1,3-diyne indole derivatives with hydroxylamine in PEG-400, as an eco-friendly solvent, under relatively mild conditions. The synthesis of the starting 1,3-diyne indole derivatives was performed by the aerobic self-coupling of diversely functionalized N-propargyl indoles and N-propargyl carbazole under copper catalysis, or by the reaction of the propargyl derivatives with phenyl- or p-tolyl-acetylene under combined nickel and copper catalysis. The isoxazolation reaction was optimized, its scope and limitations were studied and a detailed reaction mechanism was proposed.
ISSN:2046-2069
DOI:10.1039/c4ra11571f