Effect of aqueous extract of Crocus sativus L. (saffron) stigma against subacute effect of diazinon on specific biomarkers in rats

In this study, the effect of aqueous extract of Crocus sativus L. (saffron) stigma was studied against subacute toxicity of diazinon (DZN) on specific biochemical markers in rats. Vitamin E (200 IU/kg) and the aqueous extract of saffron at doses 50, 100 and 200 mg/kg were injected intraperitoneally...

Full description

Saved in:
Bibliographic Details
Published in:Toxicology and industrial health 2014-03, Vol.30 (2), p.141-146
Main Authors: Moallem, Seyed Adel, Hariri, Alireza Timcheh, Mahmoudi, Mahmoud, Hosseinzadeh, Hossein
Format: Article
Language:English
Subjects:
Animals
Biomarkers
Biomarkers - blood
Blood
Crocus
Crocus - chemistry
Crocus sativus
Damage
Diazinon - adverse effects
Dinoprost - analogs & derivatives
Dinoprost - blood
Inflammation
Inflammation - drug therapy
Inflammation - etiology
Lipid Peroxidation - drug effects
Male
Markers
Neurotoxicity Syndromes - drug therapy
Neurotoxicity Syndromes - etiology
Oxidative stress
Oxidative Stress - drug effects
Pharmaceuticals
Pharmacy
Plant Extracts - pharmacology
Proteins
Rats
Rats, Wistar
Research centers
S100 Calcium Binding Protein beta Subunit - blood
Saffron
Stigma
Stresses
Toxicity
Toxicity Tests, Subacute
Toxicology
Tumor Necrosis Factor-alpha - blood
Tumor necrosis factor-TNF
Vitamin E
Vitamin E - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study, the effect of aqueous extract of Crocus sativus L. (saffron) stigma was studied against subacute toxicity of diazinon (DZN) on specific biochemical markers in rats. Vitamin E (200 IU/kg) and the aqueous extract of saffron at doses 50, 100 and 200 mg/kg were injected intraperitoneally three times per week alone or with DZN (20 mg/kg/day, orally) for 4 weeks. Red blood cell (RBC) cholinesterase activity was inhibited by DZN and this effect was not affected by vitamin E or saffron plus DZN. The levels of serum tumor necrosis factor-α (inflammation marker), direct 8-iso-prostaglandin F2α (oxidative stress marker) and soluble protein-100 β (S100β, neuronal damage marker) were increased significantly by DZN. The saffron extract inhibited the effect of DZN on these biomarkers levels. However, vitamin E was able to only reduce 8-iso-prostaglandin F2α and S100β levels. This study showed that the aqueous extract of saffron prevents DZN-induced rise of several specific inflammation, oxidative stress and neuronal damage biomarkers.
ISSN:0748-2337
1477-0393
DOI:10.1177/0748233712452609