Assembly of 3-allyl-3-ethynyl-oxindole motifs via palladium( ii )-catalyzed quaternary allylation of 3-ethynyl-3-OBoc-oxindoles

Palladium( ii )-catalyzed C3-allylation of 3-ethynyl-3-OBoc oxindole derivatives was achieved for the first time to access highly functionalized 3-allyl-3-ethynyl substituted oxindole derivatives for a broad range of substrates in very good yields (up to 94%). The synthetic applications of the allyl...

Full description

Saved in:
Bibliographic Details
Published in:RSC advances 2015-01, Vol.5 (67), p.54316-54320
Main Authors: Kumarswamyreddy, Nandarapu, Prakash, Muthuraj, Jayakumar, Samydurai, Kesavan, Venkitasamy
Format: Article
Language:English
Subjects:
Allyl compounds
Assembly
Chemical reactions
Derivatives
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Palladium( ii )-catalyzed C3-allylation of 3-ethynyl-3-OBoc oxindole derivatives was achieved for the first time to access highly functionalized 3-allyl-3-ethynyl substituted oxindole derivatives for a broad range of substrates in very good yields (up to 94%). The synthetic applications of the allylated products were explored by synthesizing five and six membered carbocyclic spirooxindoles in moderate to very good diastereoselectivities.
ISSN:2046-2069
2046-2069
DOI:10.1039/C5RA07955A