A highly efficient heterogeneous copper-catalyzed cascade reaction of 2-halobenzoic acids and amidines leading to quinazolinones

The heterogeneous cascade reaction of 2-halobenzoic acids and amidines was achieved in DMF at 60 degree C in the presence of 10 mol% of MCM-41-immobilized tridentate nitrogen copper(i) complex [MCM-41-3N-CuI] using Cs sub(2)CO sub(3) as base, yielding a variety of quinazolinone derivatives in good t...

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Bibliographic Details
Published in:RSC advances 2014-01, Vol.4 (91), p.50285-50294
Main Authors: He, Wen, Zhao, Hong, Yao, Ruiya, Cai, Mingzhong
Format: Article
Language:English
Subjects:
Cascade chemical reactions
CATALYSTS
Copper
Derivatives
Filtration
Quinazolinones
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Summary:The heterogeneous cascade reaction of 2-halobenzoic acids and amidines was achieved in DMF at 60 degree C in the presence of 10 mol% of MCM-41-immobilized tridentate nitrogen copper(i) complex [MCM-41-3N-CuI] using Cs sub(2)CO sub(3) as base, yielding a variety of quinazolinone derivatives in good to excellent yields. This heterogeneous copper catalyst can be easily prepared from commercially available and inexpensive reagents, and recovered by a simple filtration of the reaction solution and reused for at least 10 times without any decreases in activity.
ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA09379H