Isolation and Structure of a Novel Biindole Pigment Substituted with an Ethyl Group from a Metagenomic Library Derived from the Marine Sponge Halichondria okadai

We screened a colored clone from a metagenomic library derived from the marine sponge Halichondria okadai. We isolated a yellow pigment, halichrome A (1), which was structurally elucidated to be a biindole, exhibited cytotoxicity against B16 melanoma cells and was substituted with an ethyl group. To...

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Bibliographic Details
Published in:Chemistry letters 2012-07, Vol.41 (7), p.728-729
Main Authors: Abe, Takahiro, Kukita, Akira, Akiyama, Kiyotaka, Naito, Takayuki, Uemura, Daisuke
Format: Article
Language:English
Subjects:
Halichondria okadai
Libraries
Marine
Pigments
Sponges
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Summary:We screened a colored clone from a metagenomic library derived from the marine sponge Halichondria okadai. We isolated a yellow pigment, halichrome A (1), which was structurally elucidated to be a biindole, exhibited cytotoxicity against B16 melanoma cells and was substituted with an ethyl group. To the best of our knowledge, this is the first report of the isolation of a novel compound from a metagenomic library derived from a marine sponge.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2012.728