One-pot three-component synthesis of 1,2,3-triazoles using magnetic NiFe sub(2)O sub(4)-glutam ate-Cu as an efficient heterogeneous catalyst in water

A novel magnetic NiFe sub(2)O sub(4) supported glutamate-copper catalyst was prepared in a convenient and ecofriendly manner and characterized using FTIR, XRD, EDX, TEM, SEM, XPS and VSM. This magnetic catalyst exhibited excellent catalytic activity for the synthesis of a wide variety of 1,4-disubst...

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Bibliographic Details
Published in:RSC advances 2015-07, Vol.5 (73), p.59167-59185
Main Authors: Lu, Jun, Ma, Er-Qian, Liu, Yu-Heng, Li, Ya-Meng, Mo, Li-Ping, Zhang, Zhan-Hui
Format: Article
Language:English
Subjects:
Alkynes
Catalysts
Chlorides
Precursors
Synthesis
Terminals
Transmission electron microscopy
X-ray photoelectron spectroscopy
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Summary:A novel magnetic NiFe sub(2)O sub(4) supported glutamate-copper catalyst was prepared in a convenient and ecofriendly manner and characterized using FTIR, XRD, EDX, TEM, SEM, XPS and VSM. This magnetic catalyst exhibited excellent catalytic activity for the synthesis of a wide variety of 1,4-disubstituted-1,2,3-triazoles viaone-pot three-component click reactions of sodium azide, non-activated terminal alkynes, and different azide precursors such as epoxides, benzyl chlorides, and aryl boronic acids at room temperature in water. This procedure has some advantages such as an aqueous reaction medium, ambient reaction conditions, high yields, wide substrate scope, easy separation of the catalyst using an external magnet and efficient recycling.
ISSN:2046-2069
DOI:10.1039/c5ra09517d