Rapid Synthesis of 62Zn-Labeled S-Glycosylated Porphyrin as Positron Emission Tomography Tracers for In Vivo PET Imaging

Positron emission tomography (PET) with [18F]-FDG can display cancerous activity depending on glucose uptake. Consequently, different PET tracers with different metabolisms are needed for further indication. We have developed multifunctional PET agents by combining 62Zn2+ ion with laserphyrin® and b...

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Bibliographic Details
Published in:Chemistry letters 2014-06, Vol.43 (6), p.778-780
Main Authors: Tamura, Masato, Matsui, Hirofumi, Hirohara, Shiho, Kakiuchi, Kiyomi, Tanihara, Masao, Takahashi, Naruto, Nakai, Kozi, Kanai, Yasukazu, Watabe, Hiroshi, Hatazawa, Jun
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
In vivo testing
In vivo tests
Positron emission
Surgical implants
Tomography
Tracers
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Summary:Positron emission tomography (PET) with [18F]-FDG can display cancerous activity depending on glucose uptake. Consequently, different PET tracers with different metabolisms are needed for further indication. We have developed multifunctional PET agents by combining 62Zn2+ ion with laserphyrin® and bisglycosylated 5,10,15,20-tetrakis(pentafluorophenyl)porphyrins (H2Glccis-2 and H2Glctrans-2), which can be easily synthesized and have a half-life of 9 h. 62Zn-Labeled chemicals were successfully detected as PET signals in vivo and showed PDT-induced cell death by photoirradiation.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.140056