Parallel synthesis and biological evolution of quinic acid derivatives as immuno-suppressing agents against T-cell receptors

A simple protocol for the synthesis of quinic acid derivatives was established and their biological evolution against T-cells is studied. Results showed that one of the derivatives, Cyn-1324, has low toxicity on T-cells and a high effect on reducing Signal 2 of T-cell immune responses. In vitro bind...

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Bibliographic Details
Published in:RSC advances 2015-01, Vol.5 (63), p.50801-50806
Main Authors: Huang, Chih-Yu, Chen, Li-Hsun, Huang, Hsuan-Yu, Kao, Feng-Sheng, Lee, Yun-Ta, Selvaraju, Manikandan, Sun, Chung-Ming, Chen, Hueih-Min
Format: Article
Language:English
Subjects:
Atomic beam spectroscopy
Biological evolution
Blocking
Derivatives
Receptors
Spectroscopy
Synthesis
Toxicity
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Summary:A simple protocol for the synthesis of quinic acid derivatives was established and their biological evolution against T-cells is studied. Results showed that one of the derivatives, Cyn-1324, has low toxicity on T-cells and a high effect on reducing Signal 2 of T-cell immune responses. In vitro binding measurements of atomic force spectroscopy further indicated that the blocking effect of Cyn-1324 between CD28 and CD80 was about 31 plus or minus 4%. In vivo animal tests also confirmed that Cyn-1324 can reduce the allergic responses from ovalbumin-induced mice with little toxicity. Based on these observations, Cyn-1324 can be a mild immuno-suppressive candidate for future drug development.
ISSN:2046-2069
2046-2069
DOI:10.1039/c5ra06095h