Interaction of flavones with DNA in vitro: structure–activity relationships

Flavones are polyphenolic compounds endowed with diverse pharmacological and biological activities with which have many derivatives with different structures. In this work, UV-vis spectroscopy, fluorescence spectroscopy and molecular docking have been used to investigate the structure-activity relat...

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Bibliographic Details
Published in:RSC advances 2015-01, Vol.5 (42), p.33058-33066
Main Authors: Tu, Bao, Chen, Zhi-Feng, Liu, Zhi-Juan, Cheng, Li-Yang, Hu, Yan-Jun
Format: Article
Language:English
Subjects:
Deoxyribonucleic acid
Derivatives
Docking
Drugs
Hydroxyl groups
In vitro testing
Molecular structure
Spectroscopy
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Summary:Flavones are polyphenolic compounds endowed with diverse pharmacological and biological activities with which have many derivatives with different structures. In this work, UV-vis spectroscopy, fluorescence spectroscopy and molecular docking have been used to investigate the structure-activity relationship of the interaction between different flavones and DNA in vitro. From it we could know the studied flavones are all intercalate into the double helix of DNA, suggest that the same skeleton structure in flavones may the main reason for the interaction mode. At the same time, we could find that different flavones lead to different results in the interaction which results from different structure between them, such as the number of hydroxyl groups, the location of hydroxyl groups, and steric hindrance et al. These findings are important in the research about structure-activity relationships, which may meaningful for drug discovery, drug design, novel medicines design and help us understand the structure-activity relationship between flavones at the molecular level.
ISSN:2046-2069
2046-2069
DOI:10.1039/c5ra04505c