Cascade imination, Buchwald–Hartwig cross coupling and cycloaddition reaction: synthesis of pyrido[2,3-d]pyrimidines

A novel and efficient palladium catalyzed method was developed for the synthesis of wide range of pyrido[2,3- d ]pyrimidines, using readily available β-bromovinyl/aryl aldehydes and 6-amino-1,3-dialkyluracils as the starting materials with good yields. This reaction proceeds via cascade imination/Bu...

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Bibliographic Details
Published in:RSC advances 2015-01, Vol.5 (30), p.23210-23212
Main Authors: Saikia, Pallabi, Sharma, Gitarthi, Gogoi, Sanjib, Boruah, Romesh C.
Format: Article
Language:English
Subjects:
Aromatic compounds
Cascades
Cross coupling
Cycloaddition
Microwaves
Palladium
Solvents
Synthesis
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Summary:A novel and efficient palladium catalyzed method was developed for the synthesis of wide range of pyrido[2,3- d ]pyrimidines, using readily available β-bromovinyl/aryl aldehydes and 6-amino-1,3-dialkyluracils as the starting materials with good yields. This reaction proceeds via cascade imination/Buchwald–Hartwig cross coupling/cycloaddition reactions under microwave irradiation and solvent free conditions.
ISSN:2046-2069
2046-2069
DOI:10.1039/C5RA00725A