Evaluation of a Kinetic Model for Computer Simulation of Growth and Fermentation by Scheffersomyces (Pichia) stipitis Fed D-Xylose

Scheffersomyces (formly Pichia) stipitis is a potential biocatalyst for converting lignocelluloses to ethanol because the yeast natively ferments xylose. An unstructured kinetic model based upon a system of linear differential equations has been formulated that describes growth and ethanol productio...

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Bibliographic Details
Published in:Biotechnology and bioengineering 2014-08, Vol.111 (8), p.1532-1540
Main Authors: Slininger, P. J, Dien, B. S, Lomont, J. M, Bothast, R. J, Ladisch, M. R, Okos, M. R
Format: Article
Language:English
Subjects:
batch fermentation
Biocatalysts
bioreactors
cell recycle
Computer Simulation
Differential equations
equations
Ethanol
Ethanol - metabolism
ethanol fermentation
ethanol production
ethanol stripping
Ethyl alcohol
fed-batch
Fermentation
Kinetics
lignocellulose
linear models
Mathematical models
microbial growth
model validation
Models, Biological
oxygen
Oxygen - metabolism
Pichia
Pichia - growth & development
Pichia - metabolism
Pichia stipitis
Scheffersomyces stipitis
Simulation
simulation models
Xylose
Xylose - metabolism
Yeast
yeasts
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Summary:Scheffersomyces (formly Pichia) stipitis is a potential biocatalyst for converting lignocelluloses to ethanol because the yeast natively ferments xylose. An unstructured kinetic model based upon a system of linear differential equations has been formulated that describes growth and ethanol production as functions of ethanol, oxygen, and xylose concentrations for both growth and fermentation stages. The model was validated for various growth conditions including batch, cell recycle, batch with in situ ethanol removal and fed-batch. Integrating basic kinetic and physiological yeast properties, the model is an important predictive tool for simulating and optimizing various culture conditions and evaluating various bioreactor designs for ethanol production.
ISSN:1097-0290
0006-3592
1097-0290
DOI:10.1002/bit.25215