Antibacterial activity of copper( ii ) complexes against Staphylococcus aureus

Biofilm formation on medical implants is very difficult to overcome, since the bacteria in this form resist the host defense mechanism and antibiotic therapy. What is needed is the development of an anti-biofouling agent which will prevent the formation of a biofilm especially on periprosthetic impl...

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Bibliographic Details
Published in:RSC advances 2014-01, Vol.4 (60), p.32004-32012
Main Authors: Rajalakshmi, Subramaniyam, Fathima, Aafreen, Rao, Jonnalagadda Raghava, Nair, Balachandran Unni
Format: Article
Language:English
Subjects:
ACTIVITY
Bacteria
Biofilms
COPPER COMPOUNDS
Formations
Forming
Medical
MEDICINE
MICRO ORGANISMS
Staphylococcus aureus
Surgical implants
Therapy
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Summary:Biofilm formation on medical implants is very difficult to overcome, since the bacteria in this form resist the host defense mechanism and antibiotic therapy. What is needed is the development of an anti-biofouling agent which will prevent the formation of a biofilm especially on periprosthetic implants. In this study, the antibiofilm forming potential of two copper(ii) complexes namely, [Cu(bitpy)(dmp)](NO sub(3)) sub(2) (1) and [Cu(bitpy) sub(2)](ClO sub(4)) sub(2) (2) was studied against Staphylococcus aureusMTCC - 7443, a soil isolate. From the preliminary investigations, it became clear that the anti-staphylococcalactivity of complex 2 was better than complex 1 because of the damage the complex caused at the membrane level by inhibiting the expression of some extracellular proteins responsible for biofilm formation. Further, the antibiofilm forming nature of complex 2 was confirmed by biofilm susceptibility tests, SDS - PAGE and microscopic imaging techniques. Complex 2 can therefore be used as one of the antibiofilm forming agents to curb the formation of biofilms on medical implants.
ISSN:2046-2069
2046-2069
DOI:10.1039/c4ra03241a