Characteristic location and growth patterns of functioning pituitary adenomas: correlation with histological distribution of hormone-secreting cells in the pituitary gland

Abstract Objective To evaluate the correlation between the magnetic resonance imaging findings of functional pituitary adenomas and histological distribution of hormone-secreting cells in pituitary gland. Methods Forty-nine patients with pathologically confirmed functional micro and macro pituitary...

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Bibliographic Details
Published in:Clinical imaging 2015-09, Vol.39 (5), p.770-774
Main Authors: Baik, Jun Seung, Lee, Mi Hyun, Ahn, Kook-Jin, Choi, Hyun Seok, Jung, So Lyung, Kim, Bum-Soo, Jeun, Sin Soo, Hong, Yong-Kil
Format: Article
Language:English
Subjects:
Adenoma - pathology
Adenoma - secretion
Adrenocorticotropic Hormone - secretion
Adult
Aged
Correlation
Female
Functional pituitary adenoma
Growth Hormone - secretion
Growth hormones
Histological distribution
Hormones
Humans
Imaging
Location
Magnetic Resonance Imaging
Male
Middle Aged
MRI
Patients
Pituitary gland
Pituitary Gland - pathology
Pituitary Gland - secretion
Pituitary Neoplasms - pathology
Pituitary Neoplasms - secretion
Prolactin - secretion
Radiology
Retrospective Studies
Sinuses
Thyrotropin - secretion
Tumors
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Summary:Abstract Objective To evaluate the correlation between the magnetic resonance imaging findings of functional pituitary adenomas and histological distribution of hormone-secreting cells in pituitary gland. Methods Forty-nine patients with pathologically confirmed functional micro and macro pituitary adenomas were retrospectively reviewed for its location and growth direction. Results Micro-prolactin, micro-adrenocorticotropic hormone (ACTH), and micro-growth hormone (GH) producing adenomas showed specific location ( P -value < .01). Macro-GH and macro-thyroid-stimulating hormone producing adenomas showed specific growth direction ( P -value < .05), whereas macro-prolactin and macro-ACTH producing adenomas did not. Conclusion The functional pituitary microadenomas' location and macroadenomas' growth pattern correlate well with histological distribution of hormone-secreting cells in pituitary gland.
ISSN:0899-7071
1873-4499
DOI:10.1016/j.clinimag.2015.05.016