Comprehensive studies of pharmacokinetics and biodistribution of indocyanine green and liposomal indocyanine green by multispectral optoacoustic tomography

Real-time and continuous monitoring of systemically administered agents is an important task in pharmaceutical development. Herein, we performed a real-time continuous study of the pharmacokinetics and biodistribution of indocyanine green (ICG) and liposomal indocyanine green (Lipo-ICG) in vivo by m...

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Bibliographic Details
Published in:RSC advances 2015-01, Vol.5 (5), p.3807-3813
Main Authors: Song, Wantong, Tang, Zhaohui, Zhang, Dawei, Burton, Neal, Driessen, Wouter, Chen, Xuesi
Format: Article
Language:English
Subjects:
Blood
Formulations
Liver
Monitoring
Real time
Spleen
Tomography
Tumors
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Summary:Real-time and continuous monitoring of systemically administered agents is an important task in pharmaceutical development. Herein, we performed a real-time continuous study of the pharmacokinetics and biodistribution of indocyanine green (ICG) and liposomal indocyanine green (Lipo-ICG) in vivo by multispectral optoacoustic tomography (MSOT). By comparing the blood clearance and uptake behavior of these two ICG formulations in liver, spleen, kidney and tumor, we showed that Lipo-ICG prolonged the retention time of ICG in blood, and resulted in enhanced accumulation and retention in liver, spleen, and tumor. The results obtained from the MSOT test provided a comprehensive and continuous view of the metabolic behavior of the injected agents in different formulations. The results may also be helpful for understanding this new imaging technique.
ISSN:2046-2069
2046-2069
DOI:10.1039/c4ra09735a