Nickel-catalyzed cross coupling of non-activated alkyl halides: a mechanistic perspective

Cross coupling of non-activated alkyl halides is a potentially transformative methodology in organic synthesis. Herein we review the recent development of nickel-catalyzed coupling of non-activated alkyl halides. The current understanding of the mechanism of these coupling reactions is highlighted....

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Bibliographic Details
Published in:Chemical science (Cambridge) 2011-01, Vol.2 (10), p.1867-1886
Main Author: Hu, Xile
Format: Article
Language:English
Subjects:
Catalysis
Cross coupling
Halides
Joining
Ligands
Methodology
Nickel
Synthesis
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Summary:Cross coupling of non-activated alkyl halides is a potentially transformative methodology in organic synthesis. Herein we review the recent development of nickel-catalyzed coupling of non-activated alkyl halides. The current understanding of the mechanism of these coupling reactions is highlighted. As the mechanism is ligand-dependant, the perspective is organized according to the types of ligands employed in the catalysis.
ISSN:2041-6520
2041-6539
DOI:10.1039/c1sc00368b