Highly efficient near-infrared organic dots based on novel AEE fluorogen for specific cancer cell imaging

Near-infrared emissive organic dots with a high fluorescence quantum efficiency (AEE dots) are prepared by using an amphiphilic polymer poly(styrene- co -maleic anhydride) (PSMA) as the co-encapsulation matrix and a novel small molecule fluorogen (DPPBPA) with high near-infrared emission as the core...

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Bibliographic Details
Published in:RSC advances 2015-01, Vol.5 (46), p.36837-36844
Main Authors: Zhang, Yan, Chang, Kaiwen, Xu, Bin, Chen, Jinlong, Yan, Lulin, Ma, Suqian, Wu, Changfeng, Tian, Wenjing
Format: Article
Language:English
Subjects:
Anhydrides
Austenitic stainless steels
Binding
Carboxyl group
Emissivity
Fluorescence
Polystyrene resins
Quantum efficiency
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Summary:Near-infrared emissive organic dots with a high fluorescence quantum efficiency (AEE dots) are prepared by using an amphiphilic polymer poly(styrene- co -maleic anhydride) (PSMA) as the co-encapsulation matrix and a novel small molecule fluorogen (DPPBPA) with high near-infrared emission as the core. The PSMA dots show small particle size of about 20 nm, a large Stokes shift of 304 nm and really high fluorescence quantum efficiency of 20%. The streptavidin-dots are obtained by conjugating streptavidin to carboxyl groups on the surface of PSMA dots. These streptavidin-dots can effectively and specifically label the target cell without any nonspecific binding, such as MCF-7 cells. Together with the negligible cytotoxicity, the near-infrared emissive AEE dots are promising red fluorescent probes for future bioimaging applications.
ISSN:2046-2069
2046-2069
DOI:10.1039/C5RA04669F