Bridged-cyclodextrin supramolecular hydrogels: host–guest interaction between a cyclodextrin dimer and adamantyl substituted poly(acrylate)s

The formation of a hydrogel constructed from a cyclodextrin dimer (βCD 2 ur) and adamantyl substituted poly(acrylate) was investigated by 2D NOESY 1 H NMR and isothermal titration calorimetry (ITC). The two methods generally demonstrate enhancement of complexation as the length of the hydrophobic te...

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Bibliographic Details
Published in:RSC advances 2015-01, Vol.5 (57), p.46067-46073
Main Authors: Wang, Jie, Xu, Yisheng, Wang, Yiming, Liu, Jianjia, Xu, Jun, Li, Li, Nguyen, Hanh-Trang, Pham, Duc-Truc, Lincoln, Stephen F., Guo, Xuhong
Format: Article
Language:English
Subjects:
Carbon
Complexation
Crosslinking
Cyclodextrins
Dimers
Hydrogels
Tethers
Titration calorimetry
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Summary:The formation of a hydrogel constructed from a cyclodextrin dimer (βCD 2 ur) and adamantyl substituted poly(acrylate) was investigated by 2D NOESY 1 H NMR and isothermal titration calorimetry (ITC). The two methods generally demonstrate enhancement of complexation as the length of the hydrophobic tether increases, which is likely to be due to the cooperative effect. An optimal tether length of 6 was found to maximize the complexation between βCD 2 ur and the polymer. Increasing the tether length to twelve carbons slightly reduces the complexation affinity revealed by ITC experiments. Meanwhile, rheological analysis indicates the maximum degree of crosslinking was achieved by PAAADhn/βCD 2 ur complexation since the rigid structure of PAAAD restricts the crosslinking based on the host–guest complexation between the cyclodextrin dimer and adamantyl substituent and the competitive binding from the long alkyl tether in PAAADddn reduces the degree of crosslinking.
ISSN:2046-2069
2046-2069
DOI:10.1039/C5RA06163F