Organic–inorganic bonding in chitosan–silica hybrid networks: Physical properties

Novel biomaterials are needed for bone tissue repair with improved mechanical performance compared to classical bioceramics. The objective of this work was to characterize a hybrid filler material, which is capable to coat as a thin film porous scaffolds improving their mechanical properties for bon...

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Bibliographic Details
Published in:Journal of polymer science. Part B, Polymer physics Polymer physics, 2015-10, Vol.53 (19), p.1391-1400
Main Authors: Trujillo, Sara, Pérez‐Román, Estela, Kyritsis, Apostolos, Gómez Ribelles, José Luis, Pandis, Christos
Format: Article
Language:English
Subjects:
biocompatible materials
biomaterials
Bones
Chitosan
cytotoxicity
epoxides
GPTMS
hydrolysis
hydrophilicity
mechanical properties
Media
Networks
physical properties
polymers
Precursors
silica
silicas
Silicon dioxide
Siloxanes
Sol gel process
sol-gel
TEOS
thermal properties
tissue engineering
tissue repair
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Summary:Novel biomaterials are needed for bone tissue repair with improved mechanical performance compared to classical bioceramics. The objective of this work was to characterize a hybrid filler material, which is capable to coat as a thin film porous scaffolds improving their mechanical properties for bone tissue engineering. The hybrid filler material is a blend of chitosan and silica network formed through in situ sol–gel using tetraethylortosilicate and 3‐glycidoxypropyltrimethoxysilane (GPTMS) as silica precursors. The hypothesis was that the epoxy ring of GPTMS could react with the amino groups of chitosan in acidic media while it is also reacting the siloxane groups of hydrolyzed silica precursors. The formation of the hybrid organic–inorganic network was assessed by different physical techniques revealing changes in molecular mobility and hydrophilicity upon chemical reaction. Finally, the cytotoxicity of the samples was also evaluated by MTT assay. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2015, 53, 1391–1400
ISSN:0887-6266
1099-0488
DOI:10.1002/polb.23774