Dimethylsulfoxide induces upregulation of tumor suppressor protein PTEN through nuclear factor-κB activation in HL-60 cells

Dimethylsulfoxide (DMSO) has been known to differentiate HL60 cells into neutrophil like cells. Here, we provide an evidence for the involvement of tumor suppressor PTEN, an antagonist of phosphatidylinositol 3-kinase (PI3K) in the DMSO-induced differentiation of HL60 cells. DMSO upregulated PTEN wi...

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Bibliographic Details
Published in:Leukemia research 2005-04, Vol.29 (4), p.401-405
Main Authors: Lee, Young-Rae, Shim, Hyun-Jaung, Yu, Hong-Nu, Song, Eun-Kyung, Park, Jinny, Kwon, Kang-Beom, Park, Jin-Woo, Rho, Hye-Won, Park, Byung-Hyun, Han, Myung-Kwan, Kim, Jong-Suk
Format: Article
Language:English
Subjects:
Dimethylsulfoxide
Leukemic cell differentiation
NF-κB
PTEN
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Summary:Dimethylsulfoxide (DMSO) has been known to differentiate HL60 cells into neutrophil like cells. Here, we provide an evidence for the involvement of tumor suppressor PTEN, an antagonist of phosphatidylinositol 3-kinase (PI3K) in the DMSO-induced differentiation of HL60 cells. DMSO upregulated PTEN with unaffecting the expression of PI3K. The upregulation of PTEN by DMSO lead to the decrease of Akt phosphorylation, a downstream of PI3K. The DMSO-induced upregulation of PTEN might be mediated by NF-κB activation, which was evidenced by the blockage of DMSO-induced PTEN upregulation with an NF-κB inhibitor, pyrrolidine dithiocarbamate (PDTC).
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2004.09.010