Dimethylsulfoxide induces upregulation of tumor suppressor protein PTEN through nuclear factor-κB activation in HL-60 cells

Dimethylsulfoxide (DMSO) has been known to differentiate HL60 cells into neutrophil like cells. Here, we provide an evidence for the involvement of tumor suppressor PTEN, an antagonist of phosphatidylinositol 3-kinase (PI3K) in the DMSO-induced differentiation of HL60 cells. DMSO upregulated PTEN wi...

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Published in:Leukemia research 2005-04, Vol.29 (4), p.401-405
Main Authors: Lee, Young-Rae, Shim, Hyun-Jaung, Yu, Hong-Nu, Song, Eun-Kyung, Park, Jinny, Kwon, Kang-Beom, Park, Jin-Woo, Rho, Hye-Won, Park, Byung-Hyun, Han, Myung-Kwan, Kim, Jong-Suk
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Language:English
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Dimethylsulfoxide
Leukemic cell differentiation
NF-κB
PTEN
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cited_by cdi_FETCH-LOGICAL-c340t-d30a4ffb271dbbbd6d32b320089dc9190794d96fcdaca8bc1e7d40473e8515543
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container_end_page 405
container_issue 4
container_start_page 401
container_title Leukemia research
container_volume 29
creator Lee, Young-Rae
Shim, Hyun-Jaung
Yu, Hong-Nu
Song, Eun-Kyung
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Park, Jin-Woo
Rho, Hye-Won
Park, Byung-Hyun
Han, Myung-Kwan
Kim, Jong-Suk
description Dimethylsulfoxide (DMSO) has been known to differentiate HL60 cells into neutrophil like cells. Here, we provide an evidence for the involvement of tumor suppressor PTEN, an antagonist of phosphatidylinositol 3-kinase (PI3K) in the DMSO-induced differentiation of HL60 cells. DMSO upregulated PTEN with unaffecting the expression of PI3K. The upregulation of PTEN by DMSO lead to the decrease of Akt phosphorylation, a downstream of PI3K. The DMSO-induced upregulation of PTEN might be mediated by NF-κB activation, which was evidenced by the blockage of DMSO-induced PTEN upregulation with an NF-κB inhibitor, pyrrolidine dithiocarbamate (PDTC).
doi_str_mv 10.1016/j.leukres.2004.09.010
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subjects Dimethylsulfoxide
Leukemic cell differentiation
NF-κB
PTEN
title Dimethylsulfoxide induces upregulation of tumor suppressor protein PTEN through nuclear factor-κB activation in HL-60 cells
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