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Association of oxidative stress biomarkers with adiposity and clinical staging in women with breast cancer

Background/Objectives: Breast cancer is a disease characterised by both oxidative reactions and inflammation. However, few studies have focused on the oxidative and inflammatory biomarkers. The aim of the present study was to evaluate the association between oxidative stress markers and adiposity an...

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Published in:European journal of clinical nutrition 2015-11, Vol.69 (11), p.1256-1261
Main Authors: Carioca, A A F, Verde, S M M L, Luzia, L A, Rondó, P H C, Latorre, M R D O, Ellery, T H P, Damasceno, N R T
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cites cdi_FETCH-LOGICAL-c629t-21e8674c2a16e8160545831425f7ff48a89533ba30f4ad8464595758712ddff53
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container_issue 11
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container_title European journal of clinical nutrition
container_volume 69
creator Carioca, A A F
Verde, S M M L
Luzia, L A
Rondó, P H C
Latorre, M R D O
Ellery, T H P
Damasceno, N R T
description Background/Objectives: Breast cancer is a disease characterised by both oxidative reactions and inflammation. However, few studies have focused on the oxidative and inflammatory biomarkers. The aim of the present study was to evaluate the association between oxidative stress markers and adiposity and clinical staging, as well as the association between the oxidative and the antioxidant biomarkers of women with breast cancer. Subjects/Methods: A total of 135 cases of breast cancer occurring in 2011 and 2012 were assessed. After exclusions, 101 pre- and post-menopausal women with clinical staging I to IV were eligible to participate in the study. The anthropometric evaluation was performed by collecting data on waist circumference, body mass index and body composition. The socioeconomic and clinical profiles were determined using a standard questionnaire. For the oxidative biomarkers, thiobarbituric acid reactive substances (TBARS), oxidative DNA damage (8-hydroxy-2-deoxyguanosine (8-OHdG)), low-density lipoprotein(−) (LDL(−)), autoantibody anti-LDL(−) and liposoluble antioxidants (α-tocopherol, retinol and β-carotene) were analysed. The data were analysed using differences in the mean values, correlation tests and multiple linear regression. Results: The antioxidant levels were higher in postmenopausal women with clinical staging I and II and negative lymph nodes. The TBARS level was associated with clinical staging. Adiposity was associated with levels of retinol and 8-OHdG, whereas LDL(−), 8-OHdG and TBARS were correlated with liposoluble antioxidants after adjusting for the confounders. Conclusions: The adiposity and clinical staging of patients were associated with oxidative stress. The oxidative and antioxidant biomarkers showed a negative correlation in patients with breast cancer.
doi_str_mv 10.1038/ejcn.2015.84
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However, few studies have focused on the oxidative and inflammatory biomarkers. The aim of the present study was to evaluate the association between oxidative stress markers and adiposity and clinical staging, as well as the association between the oxidative and the antioxidant biomarkers of women with breast cancer. Subjects/Methods: A total of 135 cases of breast cancer occurring in 2011 and 2012 were assessed. After exclusions, 101 pre- and post-menopausal women with clinical staging I to IV were eligible to participate in the study. The anthropometric evaluation was performed by collecting data on waist circumference, body mass index and body composition. The socioeconomic and clinical profiles were determined using a standard questionnaire. For the oxidative biomarkers, thiobarbituric acid reactive substances (TBARS), oxidative DNA damage (8-hydroxy-2-deoxyguanosine (8-OHdG)), low-density lipoprotein(−) (LDL(−)), autoantibody anti-LDL(−) and liposoluble antioxidants (α-tocopherol, retinol and β-carotene) were analysed. The data were analysed using differences in the mean values, correlation tests and multiple linear regression. Results: The antioxidant levels were higher in postmenopausal women with clinical staging I and II and negative lymph nodes. The TBARS level was associated with clinical staging. Adiposity was associated with levels of retinol and 8-OHdG, whereas LDL(−), 8-OHdG and TBARS were correlated with liposoluble antioxidants after adjusting for the confounders. Conclusions: The adiposity and clinical staging of patients were associated with oxidative stress. 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However, few studies have focused on the oxidative and inflammatory biomarkers. The aim of the present study was to evaluate the association between oxidative stress markers and adiposity and clinical staging, as well as the association between the oxidative and the antioxidant biomarkers of women with breast cancer. Subjects/Methods: A total of 135 cases of breast cancer occurring in 2011 and 2012 were assessed. After exclusions, 101 pre- and post-menopausal women with clinical staging I to IV were eligible to participate in the study. The anthropometric evaluation was performed by collecting data on waist circumference, body mass index and body composition. The socioeconomic and clinical profiles were determined using a standard questionnaire. For the oxidative biomarkers, thiobarbituric acid reactive substances (TBARS), oxidative DNA damage (8-hydroxy-2-deoxyguanosine (8-OHdG)), low-density lipoprotein(−) (LDL(−)), autoantibody anti-LDL(−) and liposoluble antioxidants (α-tocopherol, retinol and β-carotene) were analysed. The data were analysed using differences in the mean values, correlation tests and multiple linear regression. Results: The antioxidant levels were higher in postmenopausal women with clinical staging I and II and negative lymph nodes. The TBARS level was associated with clinical staging. Adiposity was associated with levels of retinol and 8-OHdG, whereas LDL(−), 8-OHdG and TBARS were correlated with liposoluble antioxidants after adjusting for the confounders. Conclusions: The adiposity and clinical staging of patients were associated with oxidative stress. 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Verde, S M M L ; Luzia, L A ; Rondó, P H C ; Latorre, M R D O ; Ellery, T H P ; Damasceno, N R T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c629t-21e8674c2a16e8160545831425f7ff48a89533ba30f4ad8464595758712ddff53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>631/67/2327</topic><topic>692/53</topic><topic>8-Hydroxydeoxyguanosine</topic><topic>Adipose tissue</topic><topic>Adipose Tissue - metabolism</topic><topic>Adiposity</topic><topic>Adult</topic><topic>alpha-Tocopherol - blood</topic><topic>Anthropometry</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Autoantibodies</topic><topic>Autoimmunity</topic><topic>beta Carotene - blood</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Body composition</topic><topic>Body Mass Index</topic><topic>Body size</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - blood</topic><topic>Breast Neoplasms - complications</topic><topic>Breast Neoplasms - metabolism</topic><topic>Carotene</topic><topic>Clinical Nutrition</topic><topic>Data collection</topic><topic>Deoxyguanosine</topic><topic>Deoxyribonucleic acid</topic><topic>Development and progression</topic><topic>Diet</topic><topic>DNA</topic><topic>DNA Damage</topic><topic>Epidemiology</topic><topic>Evaluation</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Internal Medicine</topic><topic>Levels</topic><topic>Low density lipoprotein</topic><topic>Lymph Nodes</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine &amp; 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However, few studies have focused on the oxidative and inflammatory biomarkers. The aim of the present study was to evaluate the association between oxidative stress markers and adiposity and clinical staging, as well as the association between the oxidative and the antioxidant biomarkers of women with breast cancer. Subjects/Methods: A total of 135 cases of breast cancer occurring in 2011 and 2012 were assessed. After exclusions, 101 pre- and post-menopausal women with clinical staging I to IV were eligible to participate in the study. The anthropometric evaluation was performed by collecting data on waist circumference, body mass index and body composition. The socioeconomic and clinical profiles were determined using a standard questionnaire. For the oxidative biomarkers, thiobarbituric acid reactive substances (TBARS), oxidative DNA damage (8-hydroxy-2-deoxyguanosine (8-OHdG)), low-density lipoprotein(−) (LDL(−)), autoantibody anti-LDL(−) and liposoluble antioxidants (α-tocopherol, retinol and β-carotene) were analysed. The data were analysed using differences in the mean values, correlation tests and multiple linear regression. Results: The antioxidant levels were higher in postmenopausal women with clinical staging I and II and negative lymph nodes. The TBARS level was associated with clinical staging. Adiposity was associated with levels of retinol and 8-OHdG, whereas LDL(−), 8-OHdG and TBARS were correlated with liposoluble antioxidants after adjusting for the confounders. Conclusions: The adiposity and clinical staging of patients were associated with oxidative stress. The oxidative and antioxidant biomarkers showed a negative correlation in patients with breast cancer.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26039316</pmid><doi>10.1038/ejcn.2015.84</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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identifier ISSN: 0954-3007
ispartof European journal of clinical nutrition, 2015-11, Vol.69 (11), p.1256-1261
issn 0954-3007
1476-5640
language eng
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subjects 631/67/2327
692/53
8-Hydroxydeoxyguanosine
Adipose tissue
Adipose Tissue - metabolism
Adiposity
Adult
alpha-Tocopherol - blood
Anthropometry
Antioxidants
Antioxidants - metabolism
Autoantibodies
Autoimmunity
beta Carotene - blood
Biological markers
Biomarkers
Biomarkers - blood
Body composition
Body Mass Index
Body size
Breast cancer
Breast Neoplasms - blood
Breast Neoplasms - complications
Breast Neoplasms - metabolism
Carotene
Clinical Nutrition
Data collection
Deoxyguanosine
Deoxyribonucleic acid
Development and progression
Diet
DNA
DNA Damage
Epidemiology
Evaluation
Female
Health risk assessment
Humans
Inflammation
Internal Medicine
Levels
Low density lipoprotein
Lymph Nodes
Medical prognosis
Medicine
Medicine & Public Health
Menopause
Metabolic Diseases
Neoplasm Staging
Nutritional Status
Obesity
Obesity - blood
Obesity - complications
Obesity - metabolism
original-article
Oxidative Stress
Physiological aspects
Post-menopause
Postmenopausal women
Postmenopause
Public Health
Regression analysis
Socioeconomics
Thiobarbituric acid
Thiobarbituric Acid Reactive Substances - metabolism
Tocopherol
Vitamin A
Vitamin A - blood
Waist Circumference
β-Carotene
title Association of oxidative stress biomarkers with adiposity and clinical staging in women with breast cancer
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