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Association of oxidative stress biomarkers with adiposity and clinical staging in women with breast cancer
Background/Objectives: Breast cancer is a disease characterised by both oxidative reactions and inflammation. However, few studies have focused on the oxidative and inflammatory biomarkers. The aim of the present study was to evaluate the association between oxidative stress markers and adiposity an...
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Published in: | European journal of clinical nutrition 2015-11, Vol.69 (11), p.1256-1261 |
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container_issue | 11 |
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container_title | European journal of clinical nutrition |
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creator | Carioca, A A F Verde, S M M L Luzia, L A Rondó, P H C Latorre, M R D O Ellery, T H P Damasceno, N R T |
description | Background/Objectives:
Breast cancer is a disease characterised by both oxidative reactions and inflammation. However, few studies have focused on the oxidative and inflammatory biomarkers. The aim of the present study was to evaluate the association between oxidative stress markers and adiposity and clinical staging, as well as the association between the oxidative and the antioxidant biomarkers of women with breast cancer.
Subjects/Methods:
A total of 135 cases of breast cancer occurring in 2011 and 2012 were assessed. After exclusions, 101 pre- and post-menopausal women with clinical staging I to IV were eligible to participate in the study. The anthropometric evaluation was performed by collecting data on waist circumference, body mass index and body composition. The socioeconomic and clinical profiles were determined using a standard questionnaire. For the oxidative biomarkers, thiobarbituric acid reactive substances (TBARS), oxidative DNA damage (8-hydroxy-2-deoxyguanosine (8-OHdG)), low-density lipoprotein(−) (LDL(−)), autoantibody anti-LDL(−) and liposoluble antioxidants (α-tocopherol, retinol and β-carotene) were analysed. The data were analysed using differences in the mean values, correlation tests and multiple linear regression.
Results:
The antioxidant levels were higher in postmenopausal women with clinical staging I and II and negative lymph nodes. The TBARS level was associated with clinical staging. Adiposity was associated with levels of retinol and 8-OHdG, whereas LDL(−), 8-OHdG and TBARS were correlated with liposoluble antioxidants after adjusting for the confounders.
Conclusions:
The adiposity and clinical staging of patients were associated with oxidative stress. The oxidative and antioxidant biomarkers showed a negative correlation in patients with breast cancer. |
doi_str_mv | 10.1038/ejcn.2015.84 |
format | article |
fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1730679162</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A433878384</galeid><sourcerecordid>A433878384</sourcerecordid><originalsourceid>FETCH-LOGICAL-c629t-21e8674c2a16e8160545831425f7ff48a89533ba30f4ad8464595758712ddff53</originalsourceid><addsrcrecordid>eNp9kk1v1DAQhiMEokvhxhlZQkIcyOJvO8dVxZdUiQucLa8zznpJ7MVOKP33JGyhLVohHyx7nnnHnnmr6jnBa4KZfgt7F9cUE7HW_EG1IlzJWkiOH1Yr3AheM4zVWfWklD3Gc1DRx9UZlZg1jMhVtd-UklywY0gRJY_Sz9DOhx-AypihFLQNabD5G-SCrsK4Q7YNh1TCeI1sbJHrQwzO9jNtuxA7FCK6SgPEI7zNYMuInI0O8tPqkbd9gWc3-3n19f27Lxcf68vPHz5dbC5rJ2kz1pSAloo7aokETSQWXGhGOBVeec-11Y1gbGsZ9ty2mksuGqGEVoS2rfeCnVevj7qHnL5PUEYzhOKg722ENBVDFMNSNUTSGX35D7pPU47z6wxlc3-Y4pz_jyKKNoxJwZtbqrM9mBB9GrN1S2mz4YxppZletOoTVAcRsu1TBB_m63v8-gQ_rxaG4E4mvLqTsAPbj7uS-mkZcLkPvjmCLqdSMnhzyGEe9bUh2CzOMouzzOIs8xt_cdOEaTtA-xf-Y6Xbn5U5FDvId7p0SvAXlzfUjQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1729336549</pqid></control><display><type>article</type><title>Association of oxidative stress biomarkers with adiposity and clinical staging in women with breast cancer</title><source>Springer Nature</source><source>EZB Electronic Journals Library</source><creator>Carioca, A A F ; Verde, S M M L ; Luzia, L A ; Rondó, P H C ; Latorre, M R D O ; Ellery, T H P ; Damasceno, N R T</creator><creatorcontrib>Carioca, A A F ; Verde, S M M L ; Luzia, L A ; Rondó, P H C ; Latorre, M R D O ; Ellery, T H P ; Damasceno, N R T</creatorcontrib><description>Background/Objectives:
Breast cancer is a disease characterised by both oxidative reactions and inflammation. However, few studies have focused on the oxidative and inflammatory biomarkers. The aim of the present study was to evaluate the association between oxidative stress markers and adiposity and clinical staging, as well as the association between the oxidative and the antioxidant biomarkers of women with breast cancer.
Subjects/Methods:
A total of 135 cases of breast cancer occurring in 2011 and 2012 were assessed. After exclusions, 101 pre- and post-menopausal women with clinical staging I to IV were eligible to participate in the study. The anthropometric evaluation was performed by collecting data on waist circumference, body mass index and body composition. The socioeconomic and clinical profiles were determined using a standard questionnaire. For the oxidative biomarkers, thiobarbituric acid reactive substances (TBARS), oxidative DNA damage (8-hydroxy-2-deoxyguanosine (8-OHdG)), low-density lipoprotein(−) (LDL(−)), autoantibody anti-LDL(−) and liposoluble antioxidants (α-tocopherol, retinol and β-carotene) were analysed. The data were analysed using differences in the mean values, correlation tests and multiple linear regression.
Results:
The antioxidant levels were higher in postmenopausal women with clinical staging I and II and negative lymph nodes. The TBARS level was associated with clinical staging. Adiposity was associated with levels of retinol and 8-OHdG, whereas LDL(−), 8-OHdG and TBARS were correlated with liposoluble antioxidants after adjusting for the confounders.
Conclusions:
The adiposity and clinical staging of patients were associated with oxidative stress. The oxidative and antioxidant biomarkers showed a negative correlation in patients with breast cancer.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/ejcn.2015.84</identifier><identifier>PMID: 26039316</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67/2327 ; 692/53 ; 8-Hydroxydeoxyguanosine ; Adipose tissue ; Adipose Tissue - metabolism ; Adiposity ; Adult ; alpha-Tocopherol - blood ; Anthropometry ; Antioxidants ; Antioxidants - metabolism ; Autoantibodies ; Autoimmunity ; beta Carotene - blood ; Biological markers ; Biomarkers ; Biomarkers - blood ; Body composition ; Body Mass Index ; Body size ; Breast cancer ; Breast Neoplasms - blood ; Breast Neoplasms - complications ; Breast Neoplasms - metabolism ; Carotene ; Clinical Nutrition ; Data collection ; Deoxyguanosine ; Deoxyribonucleic acid ; Development and progression ; Diet ; DNA ; DNA Damage ; Epidemiology ; Evaluation ; Female ; Health risk assessment ; Humans ; Inflammation ; Internal Medicine ; Levels ; Low density lipoprotein ; Lymph Nodes ; Medical prognosis ; Medicine ; Medicine & Public Health ; Menopause ; Metabolic Diseases ; Neoplasm Staging ; Nutritional Status ; Obesity ; Obesity - blood ; Obesity - complications ; Obesity - metabolism ; original-article ; Oxidative Stress ; Physiological aspects ; Post-menopause ; Postmenopausal women ; Postmenopause ; Public Health ; Regression analysis ; Socioeconomics ; Thiobarbituric acid ; Thiobarbituric Acid Reactive Substances - metabolism ; Tocopherol ; Vitamin A ; Vitamin A - blood ; Waist Circumference ; β-Carotene</subject><ispartof>European journal of clinical nutrition, 2015-11, Vol.69 (11), p.1256-1261</ispartof><rights>Macmillan Publishers Limited 2015</rights><rights>COPYRIGHT 2015 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Nov 2015</rights><rights>Macmillan Publishers Limited 2015.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c629t-21e8674c2a16e8160545831425f7ff48a89533ba30f4ad8464595758712ddff53</citedby><cites>FETCH-LOGICAL-c629t-21e8674c2a16e8160545831425f7ff48a89533ba30f4ad8464595758712ddff53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26039316$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carioca, A A F</creatorcontrib><creatorcontrib>Verde, S M M L</creatorcontrib><creatorcontrib>Luzia, L A</creatorcontrib><creatorcontrib>Rondó, P H C</creatorcontrib><creatorcontrib>Latorre, M R D O</creatorcontrib><creatorcontrib>Ellery, T H P</creatorcontrib><creatorcontrib>Damasceno, N R T</creatorcontrib><title>Association of oxidative stress biomarkers with adiposity and clinical staging in women with breast cancer</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Background/Objectives:
Breast cancer is a disease characterised by both oxidative reactions and inflammation. However, few studies have focused on the oxidative and inflammatory biomarkers. The aim of the present study was to evaluate the association between oxidative stress markers and adiposity and clinical staging, as well as the association between the oxidative and the antioxidant biomarkers of women with breast cancer.
Subjects/Methods:
A total of 135 cases of breast cancer occurring in 2011 and 2012 were assessed. After exclusions, 101 pre- and post-menopausal women with clinical staging I to IV were eligible to participate in the study. The anthropometric evaluation was performed by collecting data on waist circumference, body mass index and body composition. The socioeconomic and clinical profiles were determined using a standard questionnaire. For the oxidative biomarkers, thiobarbituric acid reactive substances (TBARS), oxidative DNA damage (8-hydroxy-2-deoxyguanosine (8-OHdG)), low-density lipoprotein(−) (LDL(−)), autoantibody anti-LDL(−) and liposoluble antioxidants (α-tocopherol, retinol and β-carotene) were analysed. The data were analysed using differences in the mean values, correlation tests and multiple linear regression.
Results:
The antioxidant levels were higher in postmenopausal women with clinical staging I and II and negative lymph nodes. The TBARS level was associated with clinical staging. Adiposity was associated with levels of retinol and 8-OHdG, whereas LDL(−), 8-OHdG and TBARS were correlated with liposoluble antioxidants after adjusting for the confounders.
Conclusions:
The adiposity and clinical staging of patients were associated with oxidative stress. The oxidative and antioxidant biomarkers showed a negative correlation in patients with breast cancer.</description><subject>631/67/2327</subject><subject>692/53</subject><subject>8-Hydroxydeoxyguanosine</subject><subject>Adipose tissue</subject><subject>Adipose Tissue - metabolism</subject><subject>Adiposity</subject><subject>Adult</subject><subject>alpha-Tocopherol - blood</subject><subject>Anthropometry</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Autoantibodies</subject><subject>Autoimmunity</subject><subject>beta Carotene - blood</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Body composition</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - blood</subject><subject>Breast Neoplasms - complications</subject><subject>Breast Neoplasms - metabolism</subject><subject>Carotene</subject><subject>Clinical Nutrition</subject><subject>Data collection</subject><subject>Deoxyguanosine</subject><subject>Deoxyribonucleic acid</subject><subject>Development and progression</subject><subject>Diet</subject><subject>DNA</subject><subject>DNA Damage</subject><subject>Epidemiology</subject><subject>Evaluation</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Internal Medicine</subject><subject>Levels</subject><subject>Low density lipoprotein</subject><subject>Lymph Nodes</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Menopause</subject><subject>Metabolic Diseases</subject><subject>Neoplasm Staging</subject><subject>Nutritional Status</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - complications</subject><subject>Obesity - metabolism</subject><subject>original-article</subject><subject>Oxidative Stress</subject><subject>Physiological aspects</subject><subject>Post-menopause</subject><subject>Postmenopausal women</subject><subject>Postmenopause</subject><subject>Public Health</subject><subject>Regression analysis</subject><subject>Socioeconomics</subject><subject>Thiobarbituric acid</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Tocopherol</subject><subject>Vitamin A</subject><subject>Vitamin A - blood</subject><subject>Waist Circumference</subject><subject>β-Carotene</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kk1v1DAQhiMEokvhxhlZQkIcyOJvO8dVxZdUiQucLa8zznpJ7MVOKP33JGyhLVohHyx7nnnHnnmr6jnBa4KZfgt7F9cUE7HW_EG1IlzJWkiOH1Yr3AheM4zVWfWklD3Gc1DRx9UZlZg1jMhVtd-UklywY0gRJY_Sz9DOhx-AypihFLQNabD5G-SCrsK4Q7YNh1TCeI1sbJHrQwzO9jNtuxA7FCK6SgPEI7zNYMuInI0O8tPqkbd9gWc3-3n19f27Lxcf68vPHz5dbC5rJ2kz1pSAloo7aokETSQWXGhGOBVeec-11Y1gbGsZ9ty2mksuGqGEVoS2rfeCnVevj7qHnL5PUEYzhOKg722ENBVDFMNSNUTSGX35D7pPU47z6wxlc3-Y4pz_jyKKNoxJwZtbqrM9mBB9GrN1S2mz4YxppZletOoTVAcRsu1TBB_m63v8-gQ_rxaG4E4mvLqTsAPbj7uS-mkZcLkPvjmCLqdSMnhzyGEe9bUh2CzOMouzzOIs8xt_cdOEaTtA-xf-Y6Xbn5U5FDvId7p0SvAXlzfUjQ</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Carioca, A A F</creator><creator>Verde, S M M L</creator><creator>Luzia, L A</creator><creator>Rondó, P H C</creator><creator>Latorre, M R D O</creator><creator>Ellery, T H P</creator><creator>Damasceno, N R T</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20151101</creationdate><title>Association of oxidative stress biomarkers with adiposity and clinical staging in women with breast cancer</title><author>Carioca, A A F ; Verde, S M M L ; Luzia, L A ; Rondó, P H C ; Latorre, M R D O ; Ellery, T H P ; Damasceno, N R T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c629t-21e8674c2a16e8160545831425f7ff48a89533ba30f4ad8464595758712ddff53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>631/67/2327</topic><topic>692/53</topic><topic>8-Hydroxydeoxyguanosine</topic><topic>Adipose tissue</topic><topic>Adipose Tissue - metabolism</topic><topic>Adiposity</topic><topic>Adult</topic><topic>alpha-Tocopherol - blood</topic><topic>Anthropometry</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Autoantibodies</topic><topic>Autoimmunity</topic><topic>beta Carotene - blood</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Body composition</topic><topic>Body Mass Index</topic><topic>Body size</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - blood</topic><topic>Breast Neoplasms - complications</topic><topic>Breast Neoplasms - metabolism</topic><topic>Carotene</topic><topic>Clinical Nutrition</topic><topic>Data collection</topic><topic>Deoxyguanosine</topic><topic>Deoxyribonucleic acid</topic><topic>Development and progression</topic><topic>Diet</topic><topic>DNA</topic><topic>DNA Damage</topic><topic>Epidemiology</topic><topic>Evaluation</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Internal Medicine</topic><topic>Levels</topic><topic>Low density lipoprotein</topic><topic>Lymph Nodes</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Menopause</topic><topic>Metabolic Diseases</topic><topic>Neoplasm Staging</topic><topic>Nutritional Status</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - complications</topic><topic>Obesity - metabolism</topic><topic>original-article</topic><topic>Oxidative Stress</topic><topic>Physiological aspects</topic><topic>Post-menopause</topic><topic>Postmenopausal women</topic><topic>Postmenopause</topic><topic>Public Health</topic><topic>Regression analysis</topic><topic>Socioeconomics</topic><topic>Thiobarbituric acid</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><topic>Tocopherol</topic><topic>Vitamin A</topic><topic>Vitamin A - blood</topic><topic>Waist Circumference</topic><topic>β-Carotene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carioca, A A F</creatorcontrib><creatorcontrib>Verde, S M M L</creatorcontrib><creatorcontrib>Luzia, L A</creatorcontrib><creatorcontrib>Rondó, P H C</creatorcontrib><creatorcontrib>Latorre, M R D O</creatorcontrib><creatorcontrib>Ellery, T H P</creatorcontrib><creatorcontrib>Damasceno, N R T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carioca, A A F</au><au>Verde, S M M L</au><au>Luzia, L A</au><au>Rondó, P H C</au><au>Latorre, M R D O</au><au>Ellery, T H P</au><au>Damasceno, N R T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of oxidative stress biomarkers with adiposity and clinical staging in women with breast cancer</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>69</volume><issue>11</issue><spage>1256</spage><epage>1261</epage><pages>1256-1261</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Background/Objectives:
Breast cancer is a disease characterised by both oxidative reactions and inflammation. However, few studies have focused on the oxidative and inflammatory biomarkers. The aim of the present study was to evaluate the association between oxidative stress markers and adiposity and clinical staging, as well as the association between the oxidative and the antioxidant biomarkers of women with breast cancer.
Subjects/Methods:
A total of 135 cases of breast cancer occurring in 2011 and 2012 were assessed. After exclusions, 101 pre- and post-menopausal women with clinical staging I to IV were eligible to participate in the study. The anthropometric evaluation was performed by collecting data on waist circumference, body mass index and body composition. The socioeconomic and clinical profiles were determined using a standard questionnaire. For the oxidative biomarkers, thiobarbituric acid reactive substances (TBARS), oxidative DNA damage (8-hydroxy-2-deoxyguanosine (8-OHdG)), low-density lipoprotein(−) (LDL(−)), autoantibody anti-LDL(−) and liposoluble antioxidants (α-tocopherol, retinol and β-carotene) were analysed. The data were analysed using differences in the mean values, correlation tests and multiple linear regression.
Results:
The antioxidant levels were higher in postmenopausal women with clinical staging I and II and negative lymph nodes. The TBARS level was associated with clinical staging. Adiposity was associated with levels of retinol and 8-OHdG, whereas LDL(−), 8-OHdG and TBARS were correlated with liposoluble antioxidants after adjusting for the confounders.
Conclusions:
The adiposity and clinical staging of patients were associated with oxidative stress. The oxidative and antioxidant biomarkers showed a negative correlation in patients with breast cancer.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26039316</pmid><doi>10.1038/ejcn.2015.84</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | 631/67/2327 692/53 8-Hydroxydeoxyguanosine Adipose tissue Adipose Tissue - metabolism Adiposity Adult alpha-Tocopherol - blood Anthropometry Antioxidants Antioxidants - metabolism Autoantibodies Autoimmunity beta Carotene - blood Biological markers Biomarkers Biomarkers - blood Body composition Body Mass Index Body size Breast cancer Breast Neoplasms - blood Breast Neoplasms - complications Breast Neoplasms - metabolism Carotene Clinical Nutrition Data collection Deoxyguanosine Deoxyribonucleic acid Development and progression Diet DNA DNA Damage Epidemiology Evaluation Female Health risk assessment Humans Inflammation Internal Medicine Levels Low density lipoprotein Lymph Nodes Medical prognosis Medicine Medicine & Public Health Menopause Metabolic Diseases Neoplasm Staging Nutritional Status Obesity Obesity - blood Obesity - complications Obesity - metabolism original-article Oxidative Stress Physiological aspects Post-menopause Postmenopausal women Postmenopause Public Health Regression analysis Socioeconomics Thiobarbituric acid Thiobarbituric Acid Reactive Substances - metabolism Tocopherol Vitamin A Vitamin A - blood Waist Circumference β-Carotene |
title | Association of oxidative stress biomarkers with adiposity and clinical staging in women with breast cancer |
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