The effect of kisspeptin on the functional characteristics of isolated NK cells

• Published in: Doklady. Biological sciences 2015-09, Vol.464 (1), p.267-269
• Main Authors: Shirshev, S. V., Nekrasova, I. V., Gorbunova, O. L., Orlova, E. G., Maslennikova, I. L.
• Format: Article
• Language: English
• Subjects: Adult; Biomedical and Life Sciences; Cell Biology; Cells, Cultured; Evolutionary Biology; Female; Humans; Interferon-gamma - genetics; Interferon-gamma - metabolism; Interleukin-10 - genetics; Interleukin-10 - metabolism; Interleukin-4 - genetics; Interleukin-4 - metabolism; Killer Cells, Natural - drug effects; Killer Cells, Natural - metabolism; Kisspeptins - pharmacology; L-Selectin - genetics; L-Selectin - metabolism; Life Sciences; Plant Sciences; Transforming Growth Factor beta - genetics; Transforming Growth Factor beta - metabolism
• ISSN: 0012-4966; 1608-3105
• DOI: 10.1134/S0012496615050129

The effect of kisspeptin at concentrations typical of pregnancy on the functional activity of isolated cytokine-primed NK cells has been investigated. The hormone has been shown to promote an increase in the proportion of CD56 bright NK cells, as well as an increase in the L-selectin expression on the cell surface. Assessment of cytokine levels has shown that kisspeptin suppresses the production of IL-4, IL-10, and IFN-γ while stimulating the production of TGF-β by isolated NK cells. The overall effect of the hormone investigated consisted in the formation of a phenotype and a cytokine spectrum characteristic of the regulatory NK3 subpopulation of NK cells in pregnancy.