An overview of the vaccine adverse event reporting system (VAERS) as a surveillance system

We evaluated the Vaccine Adverse Event Reporting System (VAERS), the spontaneous reporting system for vaccine-associated adverse events in the United States, as a public health surveillance system, using evaluation guidelines from the Centers for Disease Control and Prevention. We found that VAERS i...

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Published in:Vaccine 1999-07, Vol.17 (22), p.2908-2917
Main Authors: Singleton, James A., Lloyd, Jenifer C., Mootrey, Gina T., Salive, Marcel E., Chen, Robert T.
Format: Article
Language:English
Subjects:
Adverse effects
Biological and medical sciences
Epidemiology. Vaccinations
General aspects
Infectious diseases
Medical sciences
Postmarketing surveillance
Vaccines
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container_end_page 2917
container_issue 22
container_start_page 2908
container_title Vaccine
container_volume 17
creator Singleton, James A.
Lloyd, Jenifer C.
Mootrey, Gina T.
Salive, Marcel E.
Chen, Robert T.
description We evaluated the Vaccine Adverse Event Reporting System (VAERS), the spontaneous reporting system for vaccine-associated adverse events in the United States, as a public health surveillance system, using evaluation guidelines from the Centers for Disease Control and Prevention. We found that VAERS is simple for reporters to use, flexible by design and its data are available in a timely fashion. The predictive value positive for one severe event is known to be high, but for most events is unknown. The acceptability, sensitivity and representativeness of VAERS are unknown. The study of vaccine safety is complicated by underreporting, erroneous reporting, frequent multiple exposures and multiple outcomes.
doi_str_mv 10.1016/S0264-410X(99)00132-2
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subjects Adverse effects
Biological and medical sciences
Epidemiology. Vaccinations
General aspects
Infectious diseases
Medical sciences
Postmarketing surveillance
Vaccines
title An overview of the vaccine adverse event reporting system (VAERS) as a surveillance system
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