p27 super(Kip1)-stathmin interaction influences sarcoma cell migration and invasion

Emerging evidences suggest that cyclin-dependent kinase inhibitors (CKIs) can regulate cellular functions other than cell cycle progression, such as differentiation and migration. Here, we report that cytoplasmic expression of p27 super(kip1) affects microtubule (MT) stability following cell adhesio...

Full description

Saved in:
Bibliographic Details
Published in:Cancer cell 2005-01, Vol.7 (1), p.51-63
Main Authors: Baldassarre, G, Belletti, B, Nicoloso, MS, Schiappacassi, M, Vecchione, A, Spessotto, P, Morrione, A, Canzonieri, V, Colombatti, A
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 63
container_issue 1
container_start_page 51
container_title Cancer cell
container_volume 7
creator Baldassarre, G
Belletti, B
Nicoloso, MS
Schiappacassi, M
Vecchione, A
Spessotto, P
Morrione, A
Canzonieri, V
Colombatti, A
description Emerging evidences suggest that cyclin-dependent kinase inhibitors (CKIs) can regulate cellular functions other than cell cycle progression, such as differentiation and migration. Here, we report that cytoplasmic expression of p27 super(kip1) affects microtubule (MT) stability following cell adhesion on extracellular matrix (ECM) constituents. This p27 super(kip1) activity is due to its ability to bind and impair the function of the MT-destabilizing protein stathmin. Accordingly, upregulation of p27 super(kip1) or downregulation of stathmin expression results in the inhibition of mesenchymal cell motility. Moreover, high stathmin and low cytoplasmic p27 super(kip1) expression correlate with the metastatic phenotype of human sarcomas in vivo. This study provides a functional link between proliferation and invasion of tumor cells based on diverse activities of p27 super(kip1) in different subcellular compartments.
doi_str_mv 10.1016/j.ccr.2004.11.025
format article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_17316402</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17316402</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_173164023</originalsourceid><addsrcrecordid>eNqNy70OgjAUBeAOmvj7AG6djA7UXhDQ2WhMHHUnN7VoDZTaW3x-0fgATuec5DuMzUAKkJCtHkIpL2Ip1wJAyDjtsSGkSRplIDcDNiJ6yM5Bvh2ys4tzTq3TfnEyDpYRBQz32lhubNAeVTDNp5dVq63SxAm9amrkSlcVr83N41egvXbqhdSNCeuXWJGe_nLM5of9ZXeMnG-eraZQ1IY-f7S6aamAPIFsLePkb_gGWnRIeA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17316402</pqid></control><display><type>article</type><title>p27 super(Kip1)-stathmin interaction influences sarcoma cell migration and invasion</title><source>BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS</source><creator>Baldassarre, G ; Belletti, B ; Nicoloso, MS ; Schiappacassi, M ; Vecchione, A ; Spessotto, P ; Morrione, A ; Canzonieri, V ; Colombatti, A</creator><creatorcontrib>Baldassarre, G ; Belletti, B ; Nicoloso, MS ; Schiappacassi, M ; Vecchione, A ; Spessotto, P ; Morrione, A ; Canzonieri, V ; Colombatti, A</creatorcontrib><description>Emerging evidences suggest that cyclin-dependent kinase inhibitors (CKIs) can regulate cellular functions other than cell cycle progression, such as differentiation and migration. Here, we report that cytoplasmic expression of p27 super(kip1) affects microtubule (MT) stability following cell adhesion on extracellular matrix (ECM) constituents. This p27 super(kip1) activity is due to its ability to bind and impair the function of the MT-destabilizing protein stathmin. Accordingly, upregulation of p27 super(kip1) or downregulation of stathmin expression results in the inhibition of mesenchymal cell motility. Moreover, high stathmin and low cytoplasmic p27 super(kip1) expression correlate with the metastatic phenotype of human sarcomas in vivo. This study provides a functional link between proliferation and invasion of tumor cells based on diverse activities of p27 super(kip1) in different subcellular compartments.</description><identifier>ISSN: 1535-6108</identifier><identifier>DOI: 10.1016/j.ccr.2004.11.025</identifier><language>eng</language><ispartof>Cancer cell, 2005-01, Vol.7 (1), p.51-63</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids></links><search><creatorcontrib>Baldassarre, G</creatorcontrib><creatorcontrib>Belletti, B</creatorcontrib><creatorcontrib>Nicoloso, MS</creatorcontrib><creatorcontrib>Schiappacassi, M</creatorcontrib><creatorcontrib>Vecchione, A</creatorcontrib><creatorcontrib>Spessotto, P</creatorcontrib><creatorcontrib>Morrione, A</creatorcontrib><creatorcontrib>Canzonieri, V</creatorcontrib><creatorcontrib>Colombatti, A</creatorcontrib><title>p27 super(Kip1)-stathmin interaction influences sarcoma cell migration and invasion</title><title>Cancer cell</title><description>Emerging evidences suggest that cyclin-dependent kinase inhibitors (CKIs) can regulate cellular functions other than cell cycle progression, such as differentiation and migration. Here, we report that cytoplasmic expression of p27 super(kip1) affects microtubule (MT) stability following cell adhesion on extracellular matrix (ECM) constituents. This p27 super(kip1) activity is due to its ability to bind and impair the function of the MT-destabilizing protein stathmin. Accordingly, upregulation of p27 super(kip1) or downregulation of stathmin expression results in the inhibition of mesenchymal cell motility. Moreover, high stathmin and low cytoplasmic p27 super(kip1) expression correlate with the metastatic phenotype of human sarcomas in vivo. This study provides a functional link between proliferation and invasion of tumor cells based on diverse activities of p27 super(kip1) in different subcellular compartments.</description><issn>1535-6108</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNy70OgjAUBeAOmvj7AG6djA7UXhDQ2WhMHHUnN7VoDZTaW3x-0fgATuec5DuMzUAKkJCtHkIpL2Ip1wJAyDjtsSGkSRplIDcDNiJ6yM5Bvh2ys4tzTq3TfnEyDpYRBQz32lhubNAeVTDNp5dVq63SxAm9amrkSlcVr83N41egvXbqhdSNCeuXWJGe_nLM5of9ZXeMnG-eraZQ1IY-f7S6aamAPIFsLePkb_gGWnRIeA</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Baldassarre, G</creator><creator>Belletti, B</creator><creator>Nicoloso, MS</creator><creator>Schiappacassi, M</creator><creator>Vecchione, A</creator><creator>Spessotto, P</creator><creator>Morrione, A</creator><creator>Canzonieri, V</creator><creator>Colombatti, A</creator><scope>7TO</scope><scope>H94</scope></search><sort><creationdate>20050101</creationdate><title>p27 super(Kip1)-stathmin interaction influences sarcoma cell migration and invasion</title><author>Baldassarre, G ; Belletti, B ; Nicoloso, MS ; Schiappacassi, M ; Vecchione, A ; Spessotto, P ; Morrione, A ; Canzonieri, V ; Colombatti, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_173164023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baldassarre, G</creatorcontrib><creatorcontrib>Belletti, B</creatorcontrib><creatorcontrib>Nicoloso, MS</creatorcontrib><creatorcontrib>Schiappacassi, M</creatorcontrib><creatorcontrib>Vecchione, A</creatorcontrib><creatorcontrib>Spessotto, P</creatorcontrib><creatorcontrib>Morrione, A</creatorcontrib><creatorcontrib>Canzonieri, V</creatorcontrib><creatorcontrib>Colombatti, A</creatorcontrib><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Cancer cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baldassarre, G</au><au>Belletti, B</au><au>Nicoloso, MS</au><au>Schiappacassi, M</au><au>Vecchione, A</au><au>Spessotto, P</au><au>Morrione, A</au><au>Canzonieri, V</au><au>Colombatti, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>p27 super(Kip1)-stathmin interaction influences sarcoma cell migration and invasion</atitle><jtitle>Cancer cell</jtitle><date>2005-01-01</date><risdate>2005</risdate><volume>7</volume><issue>1</issue><spage>51</spage><epage>63</epage><pages>51-63</pages><issn>1535-6108</issn><abstract>Emerging evidences suggest that cyclin-dependent kinase inhibitors (CKIs) can regulate cellular functions other than cell cycle progression, such as differentiation and migration. Here, we report that cytoplasmic expression of p27 super(kip1) affects microtubule (MT) stability following cell adhesion on extracellular matrix (ECM) constituents. This p27 super(kip1) activity is due to its ability to bind and impair the function of the MT-destabilizing protein stathmin. Accordingly, upregulation of p27 super(kip1) or downregulation of stathmin expression results in the inhibition of mesenchymal cell motility. Moreover, high stathmin and low cytoplasmic p27 super(kip1) expression correlate with the metastatic phenotype of human sarcomas in vivo. This study provides a functional link between proliferation and invasion of tumor cells based on diverse activities of p27 super(kip1) in different subcellular compartments.</abstract><doi>10.1016/j.ccr.2004.11.025</doi></addata></record>
fulltext fulltext
identifier ISSN: 1535-6108
ispartof Cancer cell, 2005-01, Vol.7 (1), p.51-63
issn 1535-6108
language eng
recordid cdi_proquest_miscellaneous_17316402
source BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS
title p27 super(Kip1)-stathmin interaction influences sarcoma cell migration and invasion
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T19%3A23%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=p27%20super(Kip1)-stathmin%20interaction%20influences%20sarcoma%20cell%20migration%20and%20invasion&rft.jtitle=Cancer%20cell&rft.au=Baldassarre,%20G&rft.date=2005-01-01&rft.volume=7&rft.issue=1&rft.spage=51&rft.epage=63&rft.pages=51-63&rft.issn=1535-6108&rft_id=info:doi/10.1016/j.ccr.2004.11.025&rft_dat=%3Cproquest%3E17316402%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-proquest_miscellaneous_173164023%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=17316402&rft_id=info:pmid/&rfr_iscdi=true