Advanced cell therapies: targeting, tracking and actuation of cells with magnetic particles

Regenerative medicine would greatly benefit from a new platform technology that enabled measurable, controllable and targeting of stem cells to a site of disease or injury in the body. Superparamagnetic iron-oxide nanoparticles offer attractive possibilities in biomedicine and can be incorporated in...

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Bibliographic Details
Published in:Regenerative medicine 2015-09, Vol.10 (6), p.757-772
Main Authors: Connell, John J, Patrick, P Stephen, Yu, Yichao, Lythgoe, Mark F, Kalber, Tammy L
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - chemistry
Calcium - chemistry
Calcium Channels - chemistry
cell tracking
Dextrans - chemistry
Ferric Compounds - chemistry
Green Fluorescent Proteins - chemistry
Humans
Insulin - genetics
magnetic actuation
Magnetic Resonance Imaging
magnetic targeting
Magnetics
Magnetite Nanoparticles - chemistry
Metal Nanoparticles - chemistry
Mice
Microscopy, Confocal
MRI
regenerative medicine
Regenerative Medicine - methods
Regenerative Medicine - trends
Reproducibility of Results
SPION
Stem Cells - cytology
Transgenes
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Summary:Regenerative medicine would greatly benefit from a new platform technology that enabled measurable, controllable and targeting of stem cells to a site of disease or injury in the body. Superparamagnetic iron-oxide nanoparticles offer attractive possibilities in biomedicine and can be incorporated into cells, affording a safe and reliable means of tagging. This review describes three current and emerging methods to enhance regenerative medicine using magnetic particles to guide therapeutic cells to a target organ; track the cells using MRI and assess their spatial localization with high precision and influence the behavior of the cell using magnetic actuation. This approach is complementary to the systemic injection of cell therapies, thus expanding the horizon of stem cell therapeutics.
ISSN:1746-0751
1746-076X
DOI:10.2217/rme.15.36