Acute and long-term alteration of chemokine mRNA expression after anti-viral and anti-inflammatory treatment in herpes simplex virus encephalitis

Mortality and morbidity rates remain high among patients with herpes simplex virus encephalitis (HSVE). Chemokine-mediated recruitment and activation of leukocytes to focal areas of viral CNS infection are crucial steps in antiviral response and clearance. However, the inflammatory reaction and cell...

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Bibliographic Details
Published in:Neuroscience letters 2005-02, Vol.374 (3), p.197-202
Main Authors: Sellner, Johann, Dvorak, Florian, Zhou, Yilin, Haas, Jürgen, Kehm, Roland, Wildemann, Brigitte, Meyding-Lamadè, Uta
Format: Article
Language:English
Subjects:
Acyclovir - therapeutic use
Animals
Anti-Inflammatory Agents - therapeutic use
Antiviral Agents - therapeutic use
Biological and medical sciences
Chemokine
Chemokines - genetics
Chemokines - metabolism
Disease Models, Animal
Drug Interactions
Drug Therapy, Combination
Encephalitis
Encephalitis, Herpes Simplex - drug therapy
Encephalitis, Herpes Simplex - metabolism
Female
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - drug effects
Herpes simplex virus
HSV-1
Human viral diseases
Infectious diseases
Medical sciences
Methylprednisolone - therapeutic use
Mice
Neuroimmunology
Reverse Transcriptase Polymerase Chain Reaction - methods
RNA, Messenger - metabolism
Time Factors
Vertebrates: nervous system and sense organs
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
Viral Load - methods
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Summary:Mortality and morbidity rates remain high among patients with herpes simplex virus encephalitis (HSVE). Chemokine-mediated recruitment and activation of leukocytes to focal areas of viral CNS infection are crucial steps in antiviral response and clearance. However, the inflammatory reaction and cellular antiviral response may enhance collateral damage to neurons and account for chronic progressive brain damage. We identified a specific mRNA expression of the interferon-gamma-inducible chemokines (CXCL9, CXCL10 and CXCL11), and RANTES (CCL5) in the acute course and long-term of experimental HSVE. This pattern was substantially altered by anti-viral and anti-inflammatory treatment. Our findings indicate a pivotal role of these chemokines in the immunopathogenesis of HSVE.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2004.10.054