Cobalt-Catalyzed Decarboxylative 2‑Benzoylation of Oxazoles and Thiazoles with α‑Oxocarboxylic Acids

Cobalt-catalyzed decarboxylative cross-coupling of oxazoles and thiazoles with α-oxocarboxylic acids was developed through an sp2 C–H bond functionalization process. This work represents the first example of cobalt-catalyzed decarboxylative C–H bond functionalization and provides an efficient means...

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Bibliographic Details
Published in:Journal of organic chemistry 2015-11, Vol.80 (21), p.11065-11072
Main Authors: Yang, Ke, Chen, Xinyong, Wang, Yuqi, Li, Wanqing, Kadi, Adnan A, Fun, Hoong-Kun, Sun, Hao, Zhang, Yan, Li, Guigen, Lu, Hongjian
Format: Article
Language:English
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Summary:Cobalt-catalyzed decarboxylative cross-coupling of oxazoles and thiazoles with α-oxocarboxylic acids was developed through an sp2 C–H bond functionalization process. This work represents the first example of cobalt-catalyzed decarboxylative C–H bond functionalization and provides an efficient means of building some important bioactive heteroaryl ketone derivatives.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.5b01450