Cobalt(III)-Catalyzed C–H Alkynylation with Bromoalkynes under Mild Conditions

Expedient cobalt-catalyzed C–H alkynylation was achieved under exceedingly mild reaction conditions. Thus, chelation-assisted direct alkynylations of heteroarenes occurred with 1-bromoalkynes and ample substrate scope. The optimized catalytic system allowed for step-economical C–H functionalizations...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2015-11, Vol.17 (21), p.5316-5319
Main Authors: Sauermann, Nicolas, González, María J, Ackermann, Lutz
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Expedient cobalt-catalyzed C–H alkynylation was achieved under exceedingly mild reaction conditions. Thus, chelation-assisted direct alkynylations of heteroarenes occurred with 1-bromoalkynes and ample substrate scope. The optimized catalytic system allowed for step-economical C–H functionalizations with a mild base K2CO3 at reaction temperatures as low as 25 °C.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b02678