Surfactant assisted pulsed two-phase electromembrane extraction followed by GC analysis for quantification of basic drugs in biological samples

In this work, a simple and efficient surfactant assisted pulsed two-phase electromembrane extraction (SA-PEME) procedure combined with gas chromatography (GC) has been developed for the determination of alfentanil, sufentanil and methadone in various samples. It has been found that the addition of a...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2016-01, Vol.117, p.485-491
Main Authors: Zahedi, Pegah, Davarani, Saied Saeed Hosseiny, Moazami, Hamid Reza, Nojavan, Saeed
Format: Article
Language:English
Subjects:
Alfentanil - analysis
Chromatography, Gas - methods
Female
Humans
Methadone - analysis
Milk, Human - chemistry
Milk, Human - drug effects
Sufentanil - analysis
Surface-Active Agents - analysis
Waste Water - analysis
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Summary:In this work, a simple and efficient surfactant assisted pulsed two-phase electromembrane extraction (SA-PEME) procedure combined with gas chromatography (GC) has been developed for the determination of alfentanil, sufentanil and methadone in various samples. It has been found that the addition of anionic surfactant causes the accumulation of the cationic analytes at the SLM/solution interface resulting in an easier transfer of the analytes into the organic phase. The method was accomplished with 1-octanol as the acceptor phase and supported liquid membrane (SLM) by means of an 80 V pulsed electrical driving force and the extraction time of 20 min. The model analytes were extracted from 3.0 mL sample solution (pH 4.0) containing 0.02% w/v surfactant (sodium dodecyl sulfate). The duty cycle of 92% and frequency of 0.357 Hz gave the best performance. Extraction recoveries in the range of 70.5-95.2% and satisfactory repeatability (7.6
ISSN:0731-7085
1873-264X
DOI:10.1016/j.jpba.2015.10.002