Gamma-hydroxybutyrate enhances mood and prosocial behavior without affecting plasma oxytocin and testosterone

Highlights • We investigated putative prosocial, mood altering and neuroendocrine effects of GHB in healthy males. • We found prosocial effects of GHB. • We found mood enhancing effects of GHB. • We found increased progesterone plasma levels after GHB intake. • Oxytocin and testosterone plasma level...

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Published in:Psychoneuroendocrinology 2015-12, Vol.62, p.1-10
Main Authors: Bosch, Oliver G, Eisenegger, Christoph, Gertsch, Jürg, von Rotz, Robin, Dornbierer, Dario, Gachet, M. Salomé, Heinrichs, Markus, Wetter, Thomas C, Seifritz, Erich, Quednow, Boris B
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - blood
Adult
Affect - drug effects
Aldosterone - blood
Altruism
Brain - drug effects
Club drug
Cross-Over Studies
Dehydroepiandrosterone - blood
Emotions - drug effects
Endocrinology & Metabolism
Fairness
Gamma-hydroxybutyric acid
Humans
Hydrocortisone - blood
Hydroxybutyrates - pharmacology
Male
Oxytocin - blood
Progesterone - blood
Psychiatry
Rape drug
Social Behavior
Sodium oxybate
Testosterone - blood
Young Adult
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Summary:Highlights • We investigated putative prosocial, mood altering and neuroendocrine effects of GHB in healthy males. • We found prosocial effects of GHB. • We found mood enhancing effects of GHB. • We found increased progesterone plasma levels after GHB intake. • Oxytocin and testosterone plasma levels, as well as HPA axis activity remained unaffected after GHB intake.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2015.07.167