The Hypoglycemic Risk of Glyburide (Glibenclamide) Compared with Modified-Release Gliclazide

Abstract Objectives The risk for hypoglycemia when taking glyburide compared with modified-release gliclazide remains to be established in older adults in routine care. We investigated the risk of a hospital encounter with hypoglycemia following a new prescription for glyburide compared with modifie...

Full description

Saved in:
Bibliographic Details
Published in:Canadian journal of diabetes 2015-11, Vol.39, p.32-40
Main Authors: Clemens, Kristin K., MD, McArthur, Eric, MSc, Dixon, Stephanie N., PhD, Fleet, Jamie L., BHSc, Hramiak, Irene, MD, Garg, Amit X., MD
Format: Article
Language:English
Subjects:
diabetes
diabète
elderly
Endocrinology & Metabolism
gliclazide
glyburide
hypoglycemia
hypoglycémie
Other
personnes âgées
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Objectives The risk for hypoglycemia when taking glyburide compared with modified-release gliclazide remains to be established in older adults in routine care. We investigated the risk of a hospital encounter with hypoglycemia following a new prescription for glyburide compared with modified-release gliclazide. Methods In 2 population-based matched retrospective cohort studies in Ontario, Canada, between 2002 and 2011, we examined older adults who were newly prescribed glyburide or gliclazide as monotherapy or in the presence of metformin. Our primary outcome was a hospital encounter with hypoglycemia assessed within 90 days. Results The baseline characteristics between matched groups were similar. Initiating glyburide vs. gliclazide as monotherapy was associated with a higher risk for a hospital encounter with hypoglycemia (69 patients of 4374 taking glyburide [1.58%] vs. 8 patients of 4374 taking gliclazide [0.18%], absolute risk increase 1.40% [95% CI 1.01% to 1.79%], number needed to harm 71 [55 to 99], odds ratio 8.63 [95% CI 4.15 to 17.93], p
ISSN:1499-2671
2352-3840
DOI:10.1016/j.jcjd.2015.09.087