Correlation of serum vascular endothelial growth factor-D concentration with clinical presentation and course of lymphangioleiomyomatosis

• Published in: Respiratory medicine 2015-11, Vol.109 (11), p.1469-1475
• Main Authors: Radzikowska, Elżbieta, Jaguś, Paulina, Sobiecka, Małgorzata, Chorostowska-Wynimko, Joanna, Wiatr, Elżbieta, Kuś, Jan, Roszkowski-Śliż, Kazimierz
• Format: Article
• Language: English
• Subjects: Adult; Age Factors; Angiomyolipoma - blood; Biomarkers, Tumor - blood; Biopsy; Carbon monoxide; Chylothorax - blood; Delayed Diagnosis; Disease; Disease Progression; Female; Humans; Kidney Neoplasms - blood; Lymphangioleiomyomatosis; Lymphangioleiomyomatosis - blood; Lymphangioleiomyomatosis - diagnosis; Lymphangioleiomyomatosis - physiopathology; Lymphangioma; Male; Middle Aged; Pneumothorax - blood; Prognosis; Pulmonary function tests; Pulmonary/Respiratory; Renal angiomyolipomas; Respiratory Function Tests; Smoking - blood; Time Factors; Tuberous sclerosis; Vascular endothelial growth factor; Vascular Endothelial Growth Factor D - blood; VEGF-D
• ISSN: 0954-6111; 1532-3064
• DOI: 10.1016/j.rmed.2015.09.005

Abstract Background Increased serum vascular endothelial growth factor D (VEGF-D) concentration has been accepted as a diagnostic marker in lymphangioleiomyomatosis (LAM). The study was performed to evaluate the correlation of VEGF-D with clinical presentation and course of LAM. Material The study group comprised of 48 women with LAM (27 with sLAM, 9 with sLAM and lymphangioma (sLAM-LYM) and 12 patients with TSC/LAM). Patients were assessed at the time of VEGF-D examination, and pulmonary function parameters were compared with those, obtained one year before. VEGF-D serum concentration was measured by ELISA method. Results Patients with TSC/LAM and sLAM-LYM displayed higher concentrations of VEGF-D than patients with sLAM (2682 ± 1347 pg/mL and 2223 ± 1184 pg/mL vs.1281 ± 791 pg/mL; p = 0.0002, p = 0.009) respectively. Patients with sLAM and VEGF-D concentration