Radioembolization as a Salvage Therapy for Heavily Pretreated Patients With Colorectal Cancer Liver Metastases: Factors That Affect Outcomes

• Published in: Clinical colorectal cancer 2015-12, Vol.14 (4), p.296-305
• Main Authors: Sofocleous, Constantinos T, Violari, Elena G, Sotirchos, Vlasios S, Shady, Waleed, Gonen, Mithat, Pandit-Taskar, Neeta, Petre, Elena N, Brody, Lynn A, Alago, William, Do, Richard K, D'Angelica, Michael I, Osborne, Joseph R, Segal, Neil H, Carrasquillo, Jorge A, Kemeny, Nancy E
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Arterially directed therapies; Carcinoembryonic Antigen - blood; Colorectal Neoplasms - pathology; Colorectal Neoplasms - therapy; Disease-Free Survival; Embolization, Therapeutic - adverse effects; Embolization, Therapeutic - methods; Female; Gastroenterology and Hepatology; Hematology, Oncology and Palliative Medicine; Hepatic malignancy; Humans; Liver Neoplasms - secondary; Liver Neoplasms - therapy; Male; Middle Aged; Retrospective Studies; Salvage Therapy - methods; Selective internal radiation therapy; SIRT; Survival Rate; Treatment Outcome; Young Adult; Yttrium Radioisotopes - administration & dosage; Yttrium-90
• ISSN: 1533-0028; 1938-0674
• DOI: 10.1016/j.clcc.2015.06.003

Micro-Abstract In this single-center study we assessed the efficacy and outcomes of radioembolization (RE) for unresectable, chemorefractory colorectal cancer liver metastases in 53 heavily pretreated patients. Median overall survival (OS) was 12.7 months and median liver progression-free survival was 4.7 months. Patients with carcinoembryonic antigen levels ≥ 90 ng/mL at the time of RE and with lymphovascular invasion on pathology of the primary had decreased OS.