The mechanisms of spatial and temporal patterning of cell-edge dynamics

Adherent cells migrate and change their shape by means of protrusion and retraction at their edges. When and where these activities occur defines the shape of the cell and the way it moves. Despite a great deal of knowledge about the structural organization, components, and biochemical reactions inv...

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Bibliographic Details
Published in:Current opinion in cell biology 2015-10, Vol.36, p.113-121
Main Author: Verkhovsky, Alexander B
Format: Article
Language:English
Subjects:
Actins - metabolism
Animals
Cell Membrane - metabolism
Cell Movement
Cell Shape
Cytoskeleton - metabolism
Humans
Internal Medicine
Signal Transduction
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Summary:Adherent cells migrate and change their shape by means of protrusion and retraction at their edges. When and where these activities occur defines the shape of the cell and the way it moves. Despite a great deal of knowledge about the structural organization, components, and biochemical reactions involved in protrusion and retraction, the origins of their spatial and temporal patterns are still poorly understood. Chemical signaling circuitry is believed to be an important source of patterning, but recent studies highlighted mechanisms based on physical forces, motion, and mechanical feedback.
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2015.09.001