Increase in myeloid-derived suppressor cells (MDSCs) associated with minimal residual disease (MRD) detection in adult acute myeloid leukemia

Myeloid-derived suppressor cells (MDSCs) are thought to help provide a cellular microenvironments in many solid tumors, in which transformed cells proliferate, acquire new mutations, and evade host immunosurveillance. In the present study, we found that MDSCs (CD33 + CD11b + HLA-DR low/neg ) in bone...

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Bibliographic Details
Published in:International journal of hematology 2015-11, Vol.102 (5), p.579-586
Main Authors: Sun, Hui, Li, Yi, Zhang, Zhi-fen, Ju, Ying, Li, Li, Zhang, Bing-chang, Liu, Bin
Format: Article
Language:English
Subjects:
Adult
Bone Marrow Cells - immunology
Bone Marrow Cells - metabolism
Bone Marrow Cells - pathology
Female
Fibrin Fibrinogen Degradation Products - immunology
Fibrin Fibrinogen Degradation Products - metabolism
Hematology
Humans
Leukemia, Myeloid, Acute - diagnosis
Leukemia, Myeloid, Acute - immunology
Leukemia, Myeloid, Acute - metabolism
Leukemia, Myeloid, Acute - pathology
Leukemia, Myeloid, Acute - therapy
Male
Medicine
Medicine & Public Health
Monocytes - immunology
Monocytes - metabolism
Monocytes - pathology
Neoplasm, Residual
Oncology
Original Article
Prognosis
Tumor Escape
WT1 Proteins - blood
WT1 Proteins - immunology
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Summary:Myeloid-derived suppressor cells (MDSCs) are thought to help provide a cellular microenvironments in many solid tumors, in which transformed cells proliferate, acquire new mutations, and evade host immunosurveillance. In the present study, we found that MDSCs (CD33 + CD11b + HLA-DR low/neg ) in bone marrow were significantly increased in adult acute myeloid leukemia (AML) patients. MDSCs levels in newly diagnosed AML patients correlated well with extramedullary infiltration and plasma D-dimer levels. Remission rates in the MDSCs > 1500 group and MDSCs 
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-015-1865-2