More accurate measurement of vancomycin minimum inhibitory concentration indicates poor outcomes in meticillin-resistant Staphylococcus aureus bacteraemia

Highlights • We evaluated the effect of vancomycin (VAN) on MRSA bacteraemia prognosis. • A VAN MIC ≥1.5 μg/mL and Charlson co-morbidity index was related to mortality. • VAN therapy did not affect the clinical prognosis. • Strains with high a VAN MIC also had high teicoplanin (TEC) and daptomycin (...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2015-11, Vol.46 (5), p.532-537
Main Authors: Shoji, Hisashi, Maeda, Masayuki, Shirakura, Tetsuro, Takuma, Takahiro, Ugajin, Kazuhisa, Fukuchi, Kunihiko, Ishino, Keiko, Niki, Yoshihito
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Bacteraemia
Bacteremia - drug therapy
Bacteremia - microbiology
Bacteremia - mortality
Female
Hospitals, University
Humans
Infectious Disease
Linezolid
Male
Methicillin-Resistant Staphylococcus aureus - drug effects
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Meticillin-resistant Staphylococcus aureus
Microbial Sensitivity Tests - methods
Middle Aged
Minimum inhibitory concentration
MRSA
Staphylococcal Infections - drug therapy
Staphylococcal Infections - microbiology
Staphylococcal Infections - mortality
Survival Analysis
Tokyo
Treatment Outcome
Vancomycin
Vancomycin - pharmacology
Vancomycin - therapeutic use
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Summary:Highlights • We evaluated the effect of vancomycin (VAN) on MRSA bacteraemia prognosis. • A VAN MIC ≥1.5 μg/mL and Charlson co-morbidity index was related to mortality. • VAN therapy did not affect the clinical prognosis. • Strains with high a VAN MIC also had high teicoplanin (TEC) and daptomycin (DAP) MICs. • TEC and DAP may not be used in patients with a high VAN MIC owing to cross-resistance.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2015.07.013