Diffusion model to describe osteogenesis within a porous titanium scaffold

In this study, we develop a two-dimensional finite element model, which is derived from an animal experiment and allows simulating osteogenesis within a porous titanium scaffold implanted in ewe's hemi-mandible during 12 weeks. The cell activity is described through diffusion equations and regu...

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Bibliographic Details
Published in:Computer methods in biomechanics and biomedical engineering 2016-01, Vol.19 (2), p.171-179
Main Authors: Schmitt, M., Allena, R., Schouman, T., Frasca, S., Collombet, J.M., Holy, X., Rouch, P.
Format: Article
Language:English
Subjects:
Animals
bone scaffold
Diffusion
Female
Finite Element Analysis
finite element method
in vivo test
Mandible - drug effects
mechanobiology
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - drug effects
Models, Biological
osteogenesis
Osteogenesis - drug effects
Porosity
Prostheses and Implants
Sheep
Tissue Scaffolds - chemistry
Titanium - pharmacology
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Summary:In this study, we develop a two-dimensional finite element model, which is derived from an animal experiment and allows simulating osteogenesis within a porous titanium scaffold implanted in ewe's hemi-mandible during 12 weeks. The cell activity is described through diffusion equations and regulated by the stress state of the structure. We compare our model to (i) histological observations and (ii) experimental data obtained from a mechanical test done on sacrificed animal. We show that our mechano-biological approach provides consistent numerical results and constitutes a useful tool to predict osteogenesis pattern.
ISSN:1025-5842
1476-8259
DOI:10.1080/10255842.2014.998207