Primary Vitreoretinal Lymphoma Masquerading as Refractory Retinitis

PURPOSETo report a case of a patient with primary vitreoretinal lymphoma masquerading as retinitis. METHODSRetrospective review of the patient's clinical, histopathological and imaging records. RESULTSCytopathology was negative for malignancy, and preliminary polymerase chain reaction results s...

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Bibliographic Details
Published in:Case reports in ophthalmology 2015, Vol.6 (3), p.345-350
Main Authors: Zloto, Ofira, Elkader, Amir E Abd, Fabian, Ido Didi, Vishnevskia-Dai, Vicktoria
Format: Report
Language:English
Online Access:Get full text
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Summary:PURPOSETo report a case of a patient with primary vitreoretinal lymphoma masquerading as retinitis. METHODSRetrospective review of the patient's clinical, histopathological and imaging records. RESULTSCytopathology was negative for malignancy, and preliminary polymerase chain reaction results supported the diagnosis of varicella zoster virus retinitis. Therefore, the patient was treated with antiviral therapy. However, under this treatment, the retinitis progressed. As a result, primary vitreoretinal lymphoma was suspected, and empirical treatment with intravitreal methotrexate injections was started. Under this treatment, the ocular features improved. Five months after initial ocular presentation and ocular resolution, the patient presented with central nervous system lymphoma. CONCLUSIONThis case should raise the awareness of the variable clinical presentations, the challenging diagnosis and treatment of primary vitreoretinal lymphoma. All cases should be continuously systemically evaluated.
ISSN:1663-2699
1663-2699
DOI:10.1159/000440762